大鼠妊娠和哺乳期的维生素D代谢
Vitamin D metabolism during pregnancy and lactation in the rat.
作者信息
Halloran B P, Barthell E N, DeLuca H F
出版信息
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5549-53. doi: 10.1073/pnas.76.11.5549.
The plasma concentration of the major vitamin D metabolites; 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D were measured during pregnancy and lactation in the adult female rat. The concentrations of these metabolites were also measured in rat pups during lactation and after weaning. The plasma concentration of 1,25-dihydroxyvitamin D in the adult female increases from a control value of 26 pg/ml to 86 pg/ml during the latter stages of pregnancy, reaches a peak of 158 pg/ml during lactation, and then returns to control levels by 3 weeks postweaning. Plasma concentrations of 24,25-dihydroxyvitamin D fall dramatically during pregnancy from a control level of 3.9 ng/ml to 1.6 ng/ml remain low during lactation, and return to control levels by 3 weeks postweaning. In the neonatal rat pup at 14 days postpartum, 1,25-dihydroxyvitamin D plasma concentration is 25 pg/ml and 24,25-dihydroxyvitamin D concentration is 2.8 ng/ml. By day 25 postpartum, 1,25-dihydroxyvitamin D concentrations reached levels of 101 pg/ml, whereas 24,25-dihydroxyvitamin D concentrations fell to 1.9 ng/ml.
在成年雌性大鼠的怀孕和哺乳期，对主要维生素D代谢产物（25-羟基维生素D、1,25-二羟基维生素D和24,25-二羟基维生素D）的血浆浓度进行了测量。在哺乳期和断奶后，也对幼鼠体内这些代谢产物的浓度进行了测量。成年雌性大鼠血浆中1,25-二羟基维生素D的浓度在怀孕后期从对照值26 pg/ml升至86 pg/ml，在哺乳期达到峰值158 pg/ml，然后在断奶后3周恢复到对照水平。24,25-二羟基维生素D的血浆浓度在怀孕期间从对照水平3.9 ng/ml急剧降至1.6 ng/ml，在哺乳期保持较低水平，并在断奶后3周恢复到对照水平。产后14天的新生幼鼠，其血浆中1,25-二羟基维生素D浓度为25 pg/ml，24,25-二羟基维生素D浓度为2.8 ng/ml。到产后25天，1,25-二羟基维生素D浓度达到101 pg/ml，而24,25-二羟基维生素D浓度降至1.9 ng/ml。
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