Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia.
J Cardiovasc Transl Res. 2013 Aug;6(4):588-603. doi: 10.1007/s12265-013-9475-y. Epub 2013 May 30.
Vitamin D deficiency is a major worldwide public health problem affecting people of all ages, from infants to the elderly. Of particular concern is the high incidence of vitamin D deficiency in women during pregnancy and lactation, leading to the exposure of the growing fetus/infant to inadequate levels of vitamin D, which is essential for normal development. Vitamin D deficiency in adulthood is linked to the etiology of hypertension and to a multitude of adverse cardiovascular outcomes. It is now well-established that the antecedents of cardiovascular disease can originate very early in life. The purpose of this review is to highlight how maternal vitamin D deficiency, and its effects in upregulating the fetal renin-angiotensin system and altering cardiomyocyte growth in the fetal heart, has the potential to program long-term vulnerability to cardiovascular disease.
维生素 D 缺乏是一个全球性的重大公共卫生问题，影响着各个年龄段的人群，从婴儿到老年人。特别值得关注的是，孕妇和哺乳期妇女维生素 D 缺乏的发生率很高，这导致正在发育的胎儿/婴儿接触到不足量的维生素 D，而维生素 D 对正常发育至关重要。成年人的维生素 D 缺乏与高血压的病因以及多种不良心血管结局有关。现在已经证实，心血管疾病的发生可以在生命早期就出现。本文的目的是强调母体维生素 D 缺乏及其对胎儿肾素-血管紧张素系统的上调作用和对胎儿心脏心肌细胞生长的改变，有可能使心血管疾病的长期脆弱性得以编程。
