7-反式-（2-吡啶乙烯基）-5H-噻唑并[3,2-a]嘧啶-5-酮：合成与药理活性
7-trans-(2-Pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones: synthesis and pharmacological activity.
作者信息
Doria G, Passarotti C, Sala R, Magrini R, Sberze P, Tibolla M, Ceserani R, Arcari G, Castello R, Toti D
出版信息
Farmaco Sci. 1985 Dec;40(12):885-94.
PMID:2936619
Abstract
A series of 7-trans-(2-pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones was synthesized and evaluated for their pharmacological activity. Some compounds were found to be effective in inhibiting restraint ulcers in the rat. Two of them also showed interesting antiinflammatory activity.
摘要
合成了一系列7-反式-（2-吡啶基乙烯基）-5H-噻唑并[3,2-a]嘧啶-5-酮，并对其药理活性进行了评估。发现一些化合物对抑制大鼠的束缚性溃疡有效。其中两种还表现出有趣的抗炎活性。
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