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Synthesis and antiulcer activity of (E)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo [1,5-a]pyrimidine-7-ones.

作者信息

Doria G, Passarotti C, Sala R, Magrini R, Sberze P, Tibolla M, Ceserani R, Castello R

出版信息

Farmaco Sci. 1986 Jun;41(6):417-29.

PMID:3743739
Abstract

A series of (E)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo-[1,5-a]pyrimidine-7-ones were synthesized and evaluated for the inhibition of stress-induced gastric ulcers in the rat after oral administration. Several molecules were found to be very active. The particularly interesting compound (E)-1-(3-chlorophenyl)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo[1,5-a]- pyrimidine-7-one was chosen for wider pharmacological investigation.

摘要

相似文献

1
Synthesis and antiulcer activity of (E)-5-[2-(3-pyridyl)ethenyl]-1H,7H-pyrazolo [1,5-a]pyrimidine-7-ones.
Farmaco Sci. 1986 Jun;41(6):417-29.
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Bicyclic compounds with potential antiulcer and/or antisecretory activity. II. 1(or 3),4,6,7-Tetrahydro-1(3)H-pyrano[3,4-d]imidazoles and 1(or 3),4,6,7-tetrahydro-1(3)H-thiopyrano[3,4-d]imidazoles.具有潜在抗溃疡和/或抗分泌活性的双环化合物。II. 1（或3），4，6，7-四氢-1（3）H-吡喃并[3,4-d]咪唑和1（或3），4，6，7-四氢-1（3）H-硫代吡喃并[3,4-d]咪唑
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