米安色林的脑电图同步效应。
Synchronizing EEG effect of mianserin.
作者信息
Bo P, Patrucco M, Savoldi F, Lottici P
出版信息
Farmaco Sci. 1985 Dec;40(12):909-20.
PMID:2936620
Abstract
The AA. report on the eegraphic, behavioral and neurovegetative effects caused by the i.v. administration of mianserin, in the rabbit. This substances induces behavioral sedation and EEG synchronization. In addition, these changes are partially reinforced with L-5-hydroxytryptophan (L-5HTP) and inhibited by pretreatment with DL-p-chlorophenylalanine (PCPA). In the light of these data, the AA. discuss the possible interactions between mianserin and neurotransmitter systems, particularly the serotoninergic one.
摘要
作者关于静脉注射米安色林对家兔脑电图、行为及神经植物性效应的报告。该物质可诱发行为性镇静及脑电图同步化。此外，L-5-羟色氨酸（L-5HTP）可部分增强这些变化，而DL-对氯苯丙氨酸（PCPA）预处理则可抑制这些变化。鉴于这些数据，作者讨论了米安色林与神经递质系统，尤其是5-羟色胺能系统之间可能的相互作用。
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