Lee Young Chan, Lee Jun Seok, Jung Ah Ra, Park Jung Min, Eun Young-Gyu
Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University Medical Center, Seoul, Korea.
Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University Graduate School, Seoul, Korea.
Clin Exp Otorhinolaryngol. 2018 Sep;11(3):205-209. doi: 10.21053/ceo.2017.01319. Epub 2018 Jan 26.
To examine the factors which affect the improvement or the recurrence of disease after intralesional steroid injection in patients with oral lichen planus (OLP).
Sixty-two patients diagnosed as OLP were treated with intralesion corticosteroid injection. To evaluate the objective severity of OLP, total severity score of OLP was assessed. To examine the factors affecting the therapeutic effect of intralesional steroid injection, factors were compared between the symptom-improved group and symptom-not-improved group. To assess the symptom of patients, patients filled in 10-cm visual analogue scale, along with an Oral Health Impact Profile-14.
Symptoms improved in 50 patients (80.6%, symptom-improved group), but not in 12 patients (symptom-not-improved group). In a comparison between both group, OLP with lip involvement was the only variable which showed significant difference (=0.008). Twenty-nine of 50 patients had recurrence of OLP (58%, recurrence group) and 21 of 50 patients did not have recurrence (42%, no-recurrence group). Statistically significant differences were not found between both groups.
This study suggested that patients suffering from OLP with lesion on the lip might not be effective in treating with intralesional corticosteroid injection.
探讨影响口腔扁平苔藓（OLP）患者病损内注射类固醇后病情改善或复发的因素。
62例诊断为OLP的患者接受病损内皮质类固醇注射治疗。为评估OLP的客观严重程度，对OLP的总严重程度评分进行评估。为研究影响病损内类固醇注射治疗效果的因素，对症状改善组和症状未改善组的因素进行比较。为评估患者症状，患者填写10厘米视觉模拟量表以及口腔健康影响程度量表-14。
50例患者症状改善（80.6%，症状改善组），12例患者症状未改善（症状未改善组）。两组比较中，累及唇部的OLP是唯一显示出显著差异的变量（P = 0.008）。50例患者中有29例OLP复发（58%，复发组），50例患者中有21例未复发（42%，未复发组）。两组之间未发现统计学上的显著差异。
本研究表明，唇部有损害的OLP患者接受病损内皮质类固醇注射治疗可能效果不佳。
