曲安奈德病灶内注射治疗溃疡性口腔扁平苔藓的短期临床评估
Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus.
作者信息
Xia Juan, Li Chunyang, Hong Yun, Yang Linglan, Huang Yulei, Cheng Bin
机构信息
Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen University, No. 56 Lingyuanxi Road, Guangzhou, Guangdong 510 055, China.
出版信息
J Oral Pathol Med. 2006 Jul;35(6):327-31. doi: 10.1111/j.1600-0714.2006.00441.x.
BACKGROUND
Efforts are made in a continued searching for novel therapies for symptomatic oral lichen planus (OLP). This study aimed to evaluate the efficacy and safety of intralesional triamcinolone acetonide (TA) injection for ulcerative OLP.
METHODS
Forty-five patients with clinical and histologically confirmed ulcerative OLP on bilateral buccal mucosa, one for treatment and the other for control, were studied. All participants received 0.5 ml TA (40 mg/ml) on experimental sites. Visual analogue scale score and lesion areas were recorded at the time of injection and 1-week interval. After 2 weeks, if the treated ulceration reduced < 81% in size, a second injection was given.
RESULTS
The treated group gave rapid relief of signs and symptoms, while the control group showed minimal decrease. 38 (84.4%) patients demonstrated complete response in ulceration size. No complications were noted with TA injections.
CONCLUSIONS
Intralesional TA injection in ulcerative OLP is effective and safe in achieving lesion and pain regression.
背景
人们一直在不断努力寻找治疗症状性口腔扁平苔藓（OLP）的新疗法。本研究旨在评估病灶内注射曲安奈德（TA）治疗溃疡性OLP的疗效和安全性。
方法
对45例双侧颊黏膜临床和组织学确诊为溃疡性OLP的患者进行研究，一侧作为治疗组，另一侧作为对照组。所有参与者在实验部位注射0.5 ml TA（40 mg/ml）。在注射时和每隔1周记录视觉模拟量表评分和病变面积。2周后，如果治疗的溃疡面积缩小<81%，则进行第二次注射。
结果
治疗组的体征和症状迅速缓解，而对照组的症状改善甚微。38例（84.4%）患者的溃疡面积完全恢复。注射TA未观察到并发症。
结论
病灶内注射TA治疗溃疡性OLP在实现病变消退和疼痛缓解方面是有效且安全的。
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