ElGhareeb Mohamed Ibrahim, Ghoneimy Soheir, Elsayed Asmaa
Department of Dermatology, Venereology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
J Cosmet Dermatol. 2023 May;22(5):1481-1487. doi: 10.1111/jocd.15622. Epub 2023 Jan 31.
Oral licen planus (OLP) is a chronic inflammatory disease and may have immunological background. Both intralesional injection of PRP and steroids succeeded in treating and decreasing recurrence of the disease.
Twenty-four participants with clinically diagnosed as OLP were enrolled in this study. We separated the patients in 2 groups, 12 patients in group A were treated by intralesional PRP every two weeks for 2 months or stopped if healing occurred earlier. Group B (12 patients) treated by intralesional Triamcinolone Acetonide (TA) (20 mg) every two weeks for 2 months or may be less if healing occurred earlier. The response of OLP lesions to treatment was evaluated by reduction of lesional areas, REU scores, and NRS scores. The patients with complete response (CR; 80%-100% reduction in the lesion area) were followed for 3 months biweekly.
There was a statistically significant decrease in REU and pain score in both groups after treatment compared to before. There was a statistically increase in frequency of side effects among patients received PRP especially pain compared to those treated by steroid. Also, recurrence of the disease after treatment during follow-up for 3 months was more significant among patients treated by PRP.
Intralesional PRP is a good and safe modality for treatment of OLP and intralesional TA. However, there were some side effects and recurrence of disease after follow-up for three months in patients treated by PRP more than those treated by TA.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，可能具有免疫背景。病灶内注射富血小板血浆（PRP）和类固醇均成功治疗了该疾病并降低了其复发率。
本研究纳入了24例临床诊断为OLP的参与者。我们将患者分为两组，A组12例患者每两周接受一次病灶内PRP治疗，共治疗2个月，若愈合提前则提前停药。B组（12例患者）每两周接受一次病灶内注射曲安奈德（TA）（20mg）治疗，共治疗2个月，若愈合提前则治疗时间可能更短。通过病灶面积缩小、REU评分和NRS评分评估OLP病灶对治疗的反应。对完全缓解（CR；病灶面积缩小80%-100%）的患者每两周随访3个月。
与治疗前相比，两组治疗后REU和疼痛评分均有统计学意义的下降。与接受类固醇治疗的患者相比，接受PRP治疗的患者副作用发生率有统计学意义的增加，尤其是疼痛。此外，在随访3个月期间，接受PRP治疗的患者疾病复发情况比接受TA治疗的患者更显著。
病灶内注射PRP是治疗OLP的一种良好且安全的方式，与病灶内注射TA相当。然而，与接受TA治疗的患者相比，接受PRP治疗的患者在随访3个月后出现了一些副作用和疾病复发。
