1 Division of Anaesthesia, Department of Medicine, School of Clinical Medicine, University of Cambridge , Cambridge, United Kingdom .
2 Department of Clinical Neurosciences, University of Cambridge , Cambridge, United Kingdom .
Brain Connect. 2018 May;8(4):245-253. doi: 10.1089/brain.2017.0489. Epub 2018 Apr 5.
The default mode network (DMN) is typically associated with off-task internal mentation, or with goal-oriented tasks that require self-referential processing such as autobiographical planning. However, recent reports suggest a broader involvement of the DMN in higher cognition. In line with this view, we report global connectivity changes that are centered on the main DMN hubs of precuneus and posterior cingulate cortex during a functional magnetic resonance imaging-based visuospatial version of the Tower of London planning task. Importantly, functional connectivity of these regions with the left caudate shows a significant relationship with faster reaction time to correct responses only during the high-demand planning condition, thus offering further evidence for the DMN's engagement during visuospatial planning. The results of this study not only provide robust evidence against the widely held notion of DMN disengagement during goal-oriented, attention-demanding, externally directed tasks but also support its involvement in a broader cognitive context with a memory-related role that extends beyond self-referential, internally directed mentation.
默认模式网络（DMN）通常与任务无关的内部思维活动相关联，或者与需要自我参照处理的目标导向任务相关联，例如自传体计划。然而，最近的报告表明 DMN 在更高认知中具有更广泛的参与。根据这一观点，我们报告了在基于功能磁共振成像的伦敦塔规划任务的视空间版本中，以顶叶和后扣带回为主要 DMN 枢纽为中心的全局连通性变化。重要的是，这些区域与左侧尾状核的功能连接仅在高需求规划条件下与正确反应的更快反应时间呈显著相关，从而为 DMN 在视空间规划中的参与提供了进一步的证据。这项研究的结果不仅提供了有力的证据，证明了在目标导向、注意力要求高、外部定向任务中 DMN 不会脱离的广泛观点是错误的，而且还支持了它在更广泛的认知背景中的参与，其与记忆相关的作用不仅限于自我参照、内部导向的思维活动。
