Chemistry Department, Tarbiat Modares University, Tehran, Iran.
Mol Divers. 2009 Nov;13(4):519-28. doi: 10.1007/s11030-009-9146-8. Epub 2009 Apr 21.
Synthesis of tetrasubstituted pyrroles by the three-component condensation reaction of acid chlorides, dialkyl acetylenedicarboxylates, and amino acids in the presence of various room-temperature ionic liquids (RTILs) as catalysts in water is reported. Among the ionic liquids used, the basic functionalized ionic liquid, butyl methyl imidazolium hydroxide [bmim]OH, was the most effective catalyst. The influence of reaction temperature, reaction time, and amount of ionic liquid on the reaction was investigated. The [bmim]OH/H(2)O catalyst system could be reused for at least five recycles without appreciable loss of efficiency.
本文报道了在各种室温离子液体（RTILs）作为催化剂存在的条件下，通过酸氯、二烷基丙炔二羧酸酯和氨基酸的三组分缩合反应在水中合成四取代吡咯。在所使用的离子液体中，碱性功能化离子液体丁基甲基咪唑氢氧化物 [bmim]OH 是最有效的催化剂。考察了反应温度、反应时间和离子液体用量对反应的影响。[bmim]OH/H(2)O 催化剂体系可重复使用至少 5 次，而效率没有明显损失。
