Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA.
Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA.
Regul Toxicol Pharmacol. 2018 Apr;94:70-74. doi: 10.1016/j.yrtph.2018.01.016. Epub 2018 Jan 28.
DAS-444Ø6-6 soybean was genetically engineered (GE) to withstand applications of three different herbicides. Tolerance to glufosinate and glyphosate is achieved through expression of the phosphinothricin acetyltransferase (PAT) and double-mutated maize 5-enolpyruvyl shikimate-3-phosphate synthase (2mEPSPS) enzymes, respectively. These proteins are expressed in currently commercialized crops and represent no novel risk. Tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) is achieved through expression of the aryloxyalkanoate dioxygenase 12 (AAD-12) enzyme, which is novel in crops. The safety of the AAD-12 protein and DAS-444Ø6-6 event was assessed for food and feed safety based on the weight of evidence and found to be as safe as non-GE soybean.
DAS-444Ø6-6 大豆经过基因工程改造，能够耐受三种不同除草剂的应用。对草甘膦和草铵膦的耐受性分别通过表达膦丝菌素乙酰转移酶（PAT）和双突变的玉米 5-烯醇式丙酮酰莽草酸-3-磷酸合酶（2mEPSPS）酶来实现。这些蛋白质在目前商业化的作物中表达，不代表新的风险。对 2,4-二氯苯氧乙酸（2,4-D）的耐受性是通过表达芳氧基烷酸双加氧酶 12（AAD-12）酶来实现的，该酶在作物中是新颖的。基于证据的权重，对 AAD-12 蛋白和 DAS-444Ø6-6 事件的食品和饲料安全性进行了评估，结果发现与非转基因大豆一样安全。
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