Yuan Li, Li Yi-Rou, Xu Xiao-Dong
Hebei Normal University, College of Life Sciences, Shijiazhuang 050024, China.
Yi Chuan. 2018 Jan 20;40(1):1-11. doi: 10.16288/j.yczz.17-397.
Chronobiology is a field of biology that examines the generation of biological rhythms in various creatures and in many parts of body, and their adaptive fitness to solar- and lunar-related periodic phenomena. The synchronization of internal circadian clocks with external timing signals confers accurate phase response and tissue homeostasis. Herein we state a series of studies on circadian rhythms and introduce the brief history of chronobiology. We also present a detailed timeline of the discoveries on molecular mechanisms controlling circadian rhythm in Drosophila, which was awarded the 2017 Nobel Prize in Physiology or Medicine. The latest findings and new perspectives are further summarized to indicate the significance of circadian research.
生物钟学是生物学的一个领域，它研究各种生物体内以及身体许多部位生物节律的产生，以及它们对与太阳和月亮相关的周期性现象的适应性。内部生物钟与外部时间信号的同步赋予了精确的相位响应和组织稳态。在此，我们阐述了一系列关于昼夜节律的研究，并介绍了生物钟学的简史。我们还展示了果蝇中控制昼夜节律分子机制的发现的详细时间线，果蝇因这一发现获得了2017年诺贝尔生理学或医学奖。进一步总结了最新发现和新观点，以表明昼夜节律研究的意义。
