Yang Chao, Yang Rui-Fu, Cui Yujun
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
Yi Chuan. 2018 Jan 20;40(1):57-65. doi: 10.16288/j.yczz.17-303.
With the development of genome sequencing and the accumulation of whole genome sequences, genome-wide association study (GWAS) has achieved remarkable advances in understanding of human complex disease, and tens of thousands of disease risk factors have been found. Meanwhile, GWAS provides a new tool for exploring the genetic mechanism of bacterial phenotypes. Since the publication of the first bacterial GWAS (BGWAS) work in 2013, there have been more than 10 reports, which reveal the genetic basis of host adaption, drug resistance and virulence, etc. These findings greatly enhance our understanding on genetics, evolution and spread of bacteria. In this review, we summarize the current methodologies, applications and problems of BGWAS and highlight its potential in future research, which aims to provide helps for the applications of BGWAS in the field of microbiology.
随着基因组测序技术的发展以及全基因组序列的积累，全基因组关联研究（GWAS）在理解人类复杂疾病方面取得了显著进展，发现了数以万计的疾病风险因素。同时，GWAS为探索细菌表型的遗传机制提供了新工具。自2013年首篇细菌全基因组关联研究（BGWAS）工作发表以来，已有10余篇报道，揭示了宿主适应性、耐药性和毒力等的遗传基础。这些发现极大地增进了我们对细菌遗传学、进化和传播的理解。在本综述中，我们总结了BGWAS的当前方法、应用和问题，并突出其在未来研究中的潜力，旨在为BGWAS在微生物学领域的应用提供帮助。
