Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK.
Leeds General Infirmary, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Arch Dis Child. 2018 Oct;103(10):981-983. doi: 10.1136/archdischild-2017-314265. Epub 2018 Jan 24.
The risk of ischaemic heart disease (IHD) death in early type 1 diabetes onset was assessed using death certification data.
The Yorkshire Register of type 1 Diabetes in Children and Young People was linked to clinically validated death certification data for those diagnosed under 15 years. Standardised mortality ratios (SMRs) were calculated using the England and Wales population and IHD death rates between 1978 and 2014 by 5-year age group and sex.
The cohort included 4382 individuals (83 097 person years). Of 156 deaths, nine were classed as IHD deaths before clinical validation. After clinical validation, 14 IHD deaths were classified, with an SMR of 13.8 (95% CI 8.2 to 23.3) and median age at death of 35.1 years (range 21.9â€"47.9 years).
There is an early emergence of death from IHD in early onset type 1 diabetes. Underascertainment of IHD deaths was present without clinical validation of death certification.
使用死亡证明数据评估早发 1 型糖尿病发病患者的缺血性心脏病（IHD）死亡风险。
将约克郡儿童和年轻人 1 型糖尿病登记处与 15 岁以下确诊患者的临床验证死亡证明数据相链接。通过年龄组和性别，使用英格兰和威尔士的人口以及 1978 年至 2014 年的 IHD 死亡率，计算标准化死亡率比（SMR）。
该队列包括 4382 名个体（83097 人年）。在 156 例死亡中，有 9 例在临床验证前被归类为 IHD 死亡。经过临床验证，共分类出 14 例 IHD 死亡，SMR 为 13.8（95%CI8.2 至 23.3），死亡时的中位年龄为 35.1 岁（范围 21.9 至 47.9 岁）。
在早发 1 型糖尿病中，IHD 导致的死亡很早就出现了。如果没有对死亡证明进行临床验证，那么 IHD 死亡的漏报情况就会存在。
