细胞如何折叠大脑皮层。
How Cells Fold the Cerebral Cortex.
机构信息
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain
出版信息
J Neurosci. 2018 Jan 24;38(4):776-783. doi: 10.1523/JNEUROSCI.1106-17.2017.
Abstract
Folding of the cerebral cortex is as highly intriguing as poorly understood. At first sight, this may appear as simple tissue crumpling inside an excessively small cranium, but the process is clearly much more complex and developmentally predetermined. Whereas theoretical modeling supports a critical role for biomechanics, experimental evidence demonstrates the fundamental role of specific progenitor cell types, cellular processes, and genetic programs on cortical folding. How Forces Fold the Cerebral Cortex, by Christopher D. Kroenke and Philip V. Bayly.
摘要
大脑皮层的折叠既令人着迷，又知之甚少。乍一看，这似乎只是脑组织在过于狭小的颅腔内的简单褶皱，但这个过程显然要复杂得多，而且在发育上是预先确定的。虽然理论模型支持生物力学的关键作用，但实验证据表明，特定祖细胞类型、细胞过程和遗传程序对皮层折叠起着根本作用。《力如何折叠大脑皮层》，作者克里斯托弗·D·克罗恩克和菲利普·V·贝利。
相似文献
1
How Cells Fold the Cerebral Cortex.细胞如何折叠大脑皮层。
J Neurosci. 2018 Jan 24;38(4):776-783. doi: 10.1523/JNEUROSCI.1106-17.2017.
2
How Forces Fold the Cerebral Cortex.力如何折叠大脑皮层。
J Neurosci. 2018 Jan 24;38(4):767-775. doi: 10.1523/JNEUROSCI.1105-17.2017.
3
Germinal zones in the developing cerebral cortex of ferret: ontogeny, cell cycle kinetics, and diversity of progenitors.雪貂发育大脑皮质中的生发区：发生、细胞周期动力学和祖细胞多样性。
Cereb Cortex. 2012 Sep;22(9):2039-54. doi: 10.1093/cercor/bhr284. Epub 2011 Oct 10.
4
A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortex.中间放射状胶质细胞在哺乳动物大脑皮层的切向扩张中的作用。
Cereb Cortex. 2011 Jul;21(7):1674-94. doi: 10.1093/cercor/bhq238. Epub 2010 Dec 2.
5
The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding.灵长类特异性基因 TMEM14B 标记外放射状胶质细胞，并促进皮质扩张和折叠。
Cell Stem Cell. 2017 Nov 2;21(5):635-649.e8. doi: 10.1016/j.stem.2017.08.013. Epub 2017 Oct 12.
6
Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.大脑皮层的回旋需要哺乳动物大脑中的 FGF 信号。
Elife. 2017 Nov 14;6:e29285. doi: 10.7554/eLife.29285.
7
Shaping the brain: The emergence of cortical structure and folding.塑造大脑：皮层结构和褶皱的出现。
Dev Cell. 2023 Dec 18;58(24):2836-2849. doi: 10.1016/j.devcel.2023.11.004.
8
The regulation of cortical neurogenesis.皮层神经发生的调控。
Curr Top Dev Biol. 2021;142:1-66. doi: 10.1016/bs.ctdb.2020.10.003. Epub 2020 Dec 26.
9
Cerebral cortex expansion and folding: what have we learned?大脑皮层的扩张与折叠：我们学到了什么？
EMBO J. 2016 May 17;35(10):1021-44. doi: 10.15252/embj.201593701. Epub 2016 Apr 7.
10
Mechanics of cortical folding: stress, growth and stability.皮质折叠的力学：应力、生长与稳定性。
Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759):20170321. doi: 10.1098/rstb.2017.0321.
引用本文的文献
1
Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.通过祖细胞扩张和粘附控制的神经元迁移相结合实现皮质折叠。
Nat Commun. 2025 Aug 28;16(1):8048. doi: 10.1038/s41467-025-62858-9.
2
Anterior cingulate folding pattern is altered in autism spectrum disorder.前扣带回折叠模式在自闭症谱系障碍中发生改变。
bioRxiv. 2025 Jun 26:2025.06.24.661411. doi: 10.1101/2025.06.24.661411.
3
Biophysical basis for brain folding and misfolding patterns in ferrets and humans.雪貂和人类大脑折叠及错误折叠模式的生物物理基础。
bioRxiv. 2025 Mar 6:2025.03.05.641682. doi: 10.1101/2025.03.05.641682.
4
Characterization of the Porcine Cingulate Sulcus Cytoarchitecture.猪扣带沟细胞构筑学特征
J Comp Neurol. 2025 Feb;533(2):e70025. doi: 10.1002/cne.70025.
5
Stress landscape of folding brain serves as a map for axonal pathfinding.折叠大脑的应力景观作为轴突路径寻找的地图。
Nat Commun. 2025 Jan 30;16(1):1187. doi: 10.1038/s41467-025-56362-3.
6
Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates.CCNB1IP1的顺式调控进化驱动灵长类动物大脑皮质大小和褶皱的逐渐增加
bioRxiv. 2024 Dec 9:2024.12.08.627376. doi: 10.1101/2024.12.08.627376.
7
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.研究人类皮质类器官中的NEUROG2谱系及相关基因表达。
Development. 2025 Jan 15;152(2). doi: 10.1242/dev.202703. Epub 2025 Jan 16.
8
YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases.神经胶质细胞中的YAP信号传导：在神经发育、再生和疾病中的关键作用
Neurosci Bull. 2025 Mar;41(3):501-519. doi: 10.1007/s12264-024-01308-w. Epub 2024 Nov 6.
9
Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex.人类胎儿大脑皮质中板下神经元的分子谱系和空间分布
Adv Sci (Weinh). 2024 Dec;11(47):e2407137. doi: 10.1002/advs.202407137. Epub 2024 Nov 4.
10
Exploring the role of different cell types on cortical folding in the developing human brain through computational modeling.通过计算建模探索不同细胞类型在人类大脑发育过程中对皮质折叠的作用。
Sci Rep. 2024 Oct 30;14(1):26103. doi: 10.1038/s41598-024-75952-7.
本文引用的文献
1
Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.通过控制神经元迁移来调节大脑皮层折叠：FLRT 黏附分子的作用
Cell. 2017 May 4;169(4):621-635.e16. doi: 10.1016/j.cell.2017.04.012.
2
Pathophysiological analyses of periventricular nodular heterotopia using gyrencephalic mammals.使用脑回哺乳动物对室管膜下结节性异位进行病理生理学分析。
Hum Mol Genet. 2017 Mar 15;26(6):1173-1181. doi: 10.1093/hmg/ddx038.
3
Induction of Expansion and Folding in Human Cerebral Organoids.人类大脑类器官中扩张和折叠的诱导
Cell Stem Cell. 2017 Mar 2;20(3):385-396.e3. doi: 10.1016/j.stem.2016.11.017. Epub 2016 Dec 29.
4
Human-specific genomic signatures of neocortical expansion.新皮质扩张的人类特异性基因组特征。
Curr Opin Neurobiol. 2017 Feb;42:33-44. doi: 10.1016/j.conb.2016.11.004. Epub 2016 Nov 29.
5
The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.类人猿特异性基因TBC1D3促进小鼠基底神经祖细胞的生成并诱导皮质折叠。
Elife. 2016 Aug 9;5:e18197. doi: 10.7554/eLife.18197.
6
A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.由 Cdh1 和 Trnp1 水平限定的外脑室下区形成的受限期。
Nat Commun. 2016 Jun 6;7:11812. doi: 10.1038/ncomms11812.
7
Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.刺猬信号通路促进基底祖细胞的扩增以及新皮层的生长和折叠。
Nat Neurosci. 2016 Jul;19(7):888-96. doi: 10.1038/nn.4307. Epub 2016 May 23.
8
Cerebral cortex expansion and folding: what have we learned?大脑皮层的扩张与折叠：我们学到了什么？
EMBO J. 2016 May 17;35(10):1021-44. doi: 10.15252/embj.201593701. Epub 2016 Apr 7.
9
Comment on "Cortical folding scales universally with surface area and thickness, not number of neurons".对《皮质折叠与表面积和厚度普遍成比例，而非与神经元数量成比例》的评论
Science. 2016 Feb 19;351(6275):825. doi: 10.1126/science.aad2029.
10
CRISPR/Cas9-mediated genome engineering of the ferret.CRISPR/Cas9介导的雪貂基因组工程
Cell Res. 2015 Dec;25(12):1372-5. doi: 10.1038/cr.2015.130. Epub 2015 Nov 13.
Zotero 插件