Lin Lin, Yuan Yinfeng, Huang Zhihui, Wang Yongjie
School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Key Laboratory of Element Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.
Neurosci Bull. 2025 Mar;41(3):501-519. doi: 10.1007/s12264-024-01308-w. Epub 2024 Nov 6.
Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.
Yes相关蛋白（YAP）是Hippo信号通路的关键转录共激活因子和下游效应分子，已成为神经细胞和神经胶质细胞的主要调节因子之一。在多种神经胶质细胞类型中都检测到了它，包括外周神经系统中的施万细胞和嗅鞘细胞，以及中枢神经系统中的放射状胶质细胞、室管膜细胞、伯格曼胶质细胞、视网膜穆勒细胞、星形胶质细胞、少突胶质细胞和小胶质细胞。随着神经科学的发展，对YAP在神经胶质细胞生理或病理过程中的功能的认识也在不断深入。在这篇综述中，我们旨在从综合的角度总结YAP在神经胶质细胞和神经胶质细胞相关神经系统疾病中的作用及潜在机制。
