Kano-Sueoka T, Cohen D M, Yamaizumi Z, Nishimura S, Mori M, Fujiki H
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5741-4. doi: 10.1073/pnas.76.11.5741.
We have identified phosphoethanolamine as the pituitary-derived growth-promoting material that specifically stimulates the rat mammary carcinoma cell line 64-24. We have been studying the growth characteristics of the 64-24 cell line, which was isolated from a highly hormone-dependent tumor and which retains in culture many characteristics of the original tumor. Previously, crude bovine pituitary extract was shown to contain a significant amount of growth-stimulating activity for these cells, and a growth factor from this extract was purified to homogeneity. This report describes the identification of the growth factor as phosphoethanolamine. Further, the biological activity of phosphoethanolamine was found to be virtually identical to that of the purified growth factor. A possible role of phosphoethanolamine in the growth of mammary tumor cells as well as of normal mammary epithelial cells and other tissues is discussed.
我们已确定磷酸乙醇胺是垂体来源的促进生长物质，它能特异性刺激大鼠乳腺癌细胞系64 - 24。我们一直在研究64 - 24细胞系的生长特性，该细胞系从高度激素依赖性肿瘤中分离出来，在培养中保留了原始肿瘤的许多特征。此前已表明，粗制牛垂体提取物对这些细胞具有显著的生长刺激活性，并且从该提取物中纯化出一种生长因子，使其达到同质。本报告描述了该生长因子被鉴定为磷酸乙醇胺。此外，发现磷酸乙醇胺的生物活性与纯化的生长因子几乎相同。文中还讨论了磷酸乙醇胺在乳腺肿瘤细胞以及正常乳腺上皮细胞和其他组织生长中的可能作用。
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