Quintal D, Jackson R
J Am Acad Dermatol. 1986 Feb;14(2 Pt 1):207-14. doi: 10.1016/s0190-9622(86)70023-6.
Familial acne conglobata is more widespread and severe than "ordinary" acne conglobata and involves unusual areas such as the antecubital fossae and ankles. Of six members in one family with familial acne conglobata, two developed large and aggressive, well-differentiated squamous cell carcinomas within their disease. One had destruction of a large part of the right cranial vault; the other had most of his second cervical vertebra destroyed by metastatic squamous cell carcinoma. Isotretinoin controlled the granulomatous acneiform lesions but had no effect on the cancers.
家族性聚合性痤疮比“普通”聚合性痤疮更广泛、更严重，且累及不寻常的部位，如肘前窝和脚踝。在一个患有家族性聚合性痤疮的家庭的六名成员中，有两人在患病期间发展为大型、侵袭性、高分化鳞状细胞癌。其中一人右侧颅顶大部分被破坏；另一人的第二颈椎大部分被转移性鳞状细胞癌破坏。异维A酸可控制肉芽肿性痤疮样病变，但对癌症无效。
