克里米亚-刚果出血热患者中的布鲁氏菌病
Brucellosis in Patients with Crimean-Congo Hemorrhagic Fever.
作者信息
Duygu Fazilet, Sari Tugba, Kaya Turan, Bulut Nermin
机构信息
Public Health Institution of Turkey, Ankara, Turkey.
Tokat State Hospital, Department of Infectious Diseases and Clinical Microbiology, Tokat, Turkey.
出版信息
J Arthropod Borne Dis. 2017 Dec 30;11(4):463-468. eCollection 2017 Dec.
BACKGROUND
Crimean-Congo hemorrhagic fever (CCHF) is a fatal zoonotic viral disease caused by infection with a tick-borne virus of the genus . In this study, we investigated the incidence of brucellosis in patients diagnosed with CCHF.
METHODS
Overall, 169 patients hospitalized with an initial diagnosis of CCHF were included in 2011 in Tokat/Turkey. Immunoglobulin M (IgM) antibodies and/or PCR results were used in the laboratory diagnosis of CCHF, while plate and standard tube agglutination (STA) tests were used to diagnose brucellosis.
RESULTS
Overall, 120 patients (79%) with positive PCR tests were diagnosed with CCHF. Five (4.16%) were also diagnosed with brucellosis based on the positive plate and STA test results. Four patients (2.36%) had negative CCHF PCR and positive STA test results.
CONCLUSION
Brucellosis and CCHF can mimic each other and that all patients with CCHF or brucellosis should be screened for both conditions.
背景
克里米亚-刚果出血热（CCHF）是一种由 属蜱传病毒感染引起的致命性人畜共患病毒性疾病。在本研究中，我们调查了诊断为 CCHF 的患者中布鲁氏菌病的发病率。
方法
2011 年，土耳其托卡特共有 169 例初步诊断为 CCHF 的住院患者纳入研究。CCHF 的实验室诊断采用免疫球蛋白 M（IgM）抗体和/或 PCR 结果，而布鲁氏菌病的诊断采用平板和标准试管凝集（STA）试验。
结果
总体而言，120 例（79%）PCR 检测呈阳性的患者被诊断为 CCHF。基于平板和 STA 试验结果，5 例（4.16%）也被诊断为布鲁氏菌病。4 例（2.36%）CCHF PCR 检测呈阴性但 STA 试验结果呈阳性。
结论
布鲁氏菌病和 CCHF 可能相互混淆，所有 CCHF 或布鲁氏菌病患者均应同时筛查这两种疾病。
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