Sheng Guorong, Ma Shicong, Bai Songlin, Mao Jianming, Lu Ping, Wang Yanguang
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Chem Commun (Camb). 2018 Feb 11;54(12):1529-1532. doi: 10.1039/c7cc09488d. Epub 2018 Jan 25.
3-Diazoindolin-2-imines reacted with chiral 2-(phenylamino)ethanols under copper catalysis to furnish chiral spiro[indoline-3,2'-oxazolidin]-2-imines in good yields with excellent diastereoselectivity. The reaction undergoes a copper-catalyzed cascade process involving the formation of copper carbene, C-N coupling, and C-O coupling.
3-重氮吲哚-2-亚胺在铜催化下与手性2-(苯基氨基)乙醇反应，以良好的产率和优异的非对映选择性得到手性螺[吲哚啉-3,2'-恶唑烷]-2-亚胺。该反应经历了一个铜催化的串联过程，包括卡宾铜的形成、C-N偶联和C-O偶联。
