College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China.
Nanoscale. 2018 Feb 8;10(6):2866-2875. doi: 10.1039/c7nr09237g.
In this study, a versatile tumor-targeted and multi-stimuli-responsive drug delivery vehicle (Se particle@porous silica-folic acid-copper sulfide/doxorubicin (Se@SiO-FA-CuS/DOX)) was fabricated for combined photothermal therapy with chemotherapy in cancer treatment. Due to excellent targeting ability, the Se@SiO-FA-CuS/DOX nanocomposites actively accumulated in tumor tissues and thus provided photothermal therapy under NIR irradiation and chemotherapy through the release of DOX and Se. Owing to the synergistic effect of chemotherapy (Se and DOX) and photothermal therapy, the Se@SiO-FA-CuS/DOX nanocomposites could efficiently inhibit cancer cells both in vitro and in vivo and even completely eliminate tumors. Moreover, as the toxicity of DOX could be reduced by Se, the treatment using Se@SiO-FA-CuS/DOX nanocomposites exhibited no appreciable adverse reactions. Thus, the Se@SiO-FA-CuS/DOX nanocomposites have great potential as a multifunctional nanoplatform in future clinical applications.
在这项研究中，制备了一种多功能的肿瘤靶向和多刺激响应药物输送载体（Se 颗粒@多孔硅酸钠-叶酸-硫化铜/阿霉素（Se@SiO-FA-CuS/DOX）），用于癌症治疗中的光热治疗与化学疗法联合治疗。由于具有优异的靶向能力，Se@SiO-FA-CuS/DOX 纳米复合材料在近红外光照射下主动聚集在肿瘤组织中，通过释放 DOX 和 Se 提供光热治疗和化学疗法。由于化学疗法（Se 和 DOX）和光热疗法的协同作用，Se@SiO-FA-CuS/DOX 纳米复合材料在体外和体内都能有效地抑制癌细胞，甚至可以完全消除肿瘤。此外，由于 Se 可以降低 DOX 的毒性，因此使用 Se@SiO-FA-CuS/DOX 纳米复合材料进行治疗没有明显的不良反应。因此，Se@SiO-FA-CuS/DOX 纳米复合材料作为一种多功能纳米平台，在未来的临床应用中具有巨大的潜力。
