Peng Shuwen, He Yuanyuan, Er Murat, Sheng Yuanzhi, Gu Yueqing, Chen Haiyan
Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China.
Biomater Sci. 2017 Feb 28;5(3):475-484. doi: 10.1039/c6bm00626d.
Near-infrared (NIR) photothermal therapy (PTT) is a new approach to ablate cancer without affecting normal tissues. A pivotal concern of PPT is to develop photo-responsive agents with high biocompatibility as well as effective photothermal conversion efficiency. Copper sulfide (CuS) nanoparticles prepared are characterized by their low synthesis cost, wide NIR absorption range, good biocompatibility and favorable NIR photothermal conversion efficiency. CuS nanoparticles were then coated with mesoporous silicon dioxide (SiO) by the Stober method, and further loaded with anticancer drug doxorubicin (DOX). The nanocomposites obtained were named CuS@MSN-DOX. The infrared thermal imaging of CuS@MSN-DOX demonstrated its favorable photothermal efficacy. The potential of CuS@MSN-DOX utilized as a multifunctional platform for combined PPT and chemotherapy was exploited both at the cell level and in a mice model. The result demonstrated that CuS@MSN-DOX was endowed with the synergistic effect of chemo-photothermal therapy, which confirmed that it is a promising candidate for combined therapy of cancer.
近红外（NIR）光热疗法（PTT）是一种在不影响正常组织的情况下消融癌症的新方法。光热疗法的一个关键问题是开发具有高生物相容性以及有效光热转换效率的光响应剂。所制备的硫化铜（CuS）纳米颗粒具有合成成本低、近红外吸收范围宽、生物相容性好和良好的近红外光热转换效率等特点。然后通过斯托伯方法用介孔二氧化硅（SiO₂）包覆CuS纳米颗粒，并进一步负载抗癌药物阿霉素（DOX）。所得到的纳米复合材料被命名为CuS@MSN-DOX。CuS@MSN-DOX的红外热成像显示出其良好的光热疗效。在细胞水平和小鼠模型中都探索了CuS@MSN-DOX用作光热疗法和化疗联合的多功能平台的潜力。结果表明，CuS@MSN-DOX具有化疗-光热疗法的协同作用，这证实了它是癌症联合治疗的一个有前景的候选者。
