RTI Health Solutions, Research Triangle Park, NC, USA.
RTI Health Solutions, Manchester, UK.
Am J Clin Dermatol. 2018 Apr;19(2):267-274. doi: 10.1007/s40257-017-0331-8.
The Urticaria Activity Score summed over 7 days (UAS7) assesses the itch severity and hive count in chronic spontaneous urticaria (CSU) using once- or twice-daily diary-based documentation.
The aim of this study was to evaluate the comparability of twice-daily versus once-daily versions of the UAS and the resulting UAS7 values.
Data came from the ASSURE-CSU study. The twice-daily and once-daily UAS7 was calculated from morning and evening ratings, as well as from exact 24-h evening ratings of hive count and itch severity, respectively. Three UAS7 scores were computed: UAS7 twice daily (UAS7), UAS7 once daily for maximum itch (UAS7), and UAS7 once daily for average itch (UAS7). UAS7 values were assigned to five score bands (0, 1-6, 7-15, 16-27, 28-42), reflecting urticaria-free to severe disease activity. The score values and score band ratios of the UAS7 and UAS7 versions were compared and assessed for correlation by weighted Cohen's kappa statistics.
Data from 614 patients were analyzed. All three versions of the UAS7 yielded very similar results, with a mean (standard deviation) UAS7, UAS7, and UAS7 of 17.3 (10.49), 17.7 (8.90), and 16.2 (8.68), respectively. Correlation coefficients between UAS7 and UAS7, UAS7 and UAS7, and UAS7 and UAS7 were 0.94, 0.95, and 0.99, respectively, showing very high positive pairwise correlation. The weighted kappa coefficient, κ (95% confidence interval) was 0.78 (0.75-0.82) for UAS7 versus UAS7, and 0.82 (0.78-0.85) for UAS7 versus UAS7, demonstrating substantial agreement.
The once- and twice-daily UAS7 scores were highly consistent, supporting the use of either version when evaluating CSU activity.
7 天荨麻疹活动评分（UAS7）通过每日一次或两次的日记记录来评估慢性自发性荨麻疹（CSU）的瘙痒严重程度和风团数量。
本研究旨在评估 UAS 的每日两次和每日一次版本的可比性，以及由此产生的 UAS7 值。
数据来自 ASSURE-CSU 研究。UAS7 的每日两次和每日一次版本分别根据早上和晚上的评分以及风团数量和瘙痒严重程度的准确 24 小时晚上评分计算得出。计算了三种 UAS7 评分：UAS7 每日两次（UAS7）、UAS7 每日一次以最大瘙痒（UAS7）和 UAS7 每日一次以平均瘙痒（UAS7）。UAS7 值被分配到五个评分区间（0、1-6、7-15、16-27、28-42），反映无荨麻疹至严重疾病活动。通过加权 Cohen's kappa 统计评估 UAS7 和 UAS7 版本的评分值和评分区间比值，并评估相关性。
对 614 名患者的数据进行了分析。UAS7 的所有三个版本都产生了非常相似的结果，UAS7 的平均值（标准差）分别为 17.3（10.49）、17.7（8.90）和 16.2（8.68）。UAS7 与 UAS7、UAS7 与 UAS7 和 UAS7 与 UAS7 的相关系数分别为 0.94、0.95 和 0.99，显示出非常高的正相关性。UAS7 与 UAS7、UAS7 与 UAS7 的加权 kappa 系数，κ（95%置信区间）分别为 0.78（0.75-0.82）和 0.82（0.78-0.85），表明存在实质性一致性。
每日一次和两次 UAS7 评分高度一致，支持在评估 CSU 活动时使用任一个版本。
