Unidad de Neurobiología Aplicada, CEMIC-CONICET, Buenos Aires, Argentina.
Brain Struct Funct. 2018 Mar;223(2):981-985. doi: 10.1007/s00429-018-1609-1. Epub 2018 Jan 24.
The subcortical white matter (SWM) has been traditionally considered as a site for passive-neutral-information transfer through cerebral cortex association and projection fibers. Yet, the presence of subcortical neuronal and glial "interstitial" cells expressing immunolabelled neurotransmitters/neuromodulators and synaptic vesicular proteins, and recent immunohistochemical and electrophysiological observations on the rat visual cortex as well as interactive regulation of myelinating processes support the possibility that SWM nests subcortical, regionally variable, distributed neuronal-glial circuits, that could influence information transfer. Their hypothetical involvement in regulating the timing and signal transfer probability at the SWM axonal components ought to be considered and experimentally analysed. Thus, the "interstitial" neuronal cells-associated with local glial cells-traditionally considered to be vestigial and functionally inert under normal conditions, they may well turn to be critical in regulating information transfer at the SWM.
皮质下白质（SWM）传统上被认为是通过大脑皮层的联合和投射纤维进行被动、中性信息传递的场所。然而，存在表达免疫标记神经递质/神经调质和突触小泡蛋白的皮质下神经元和神经胶质“间质”细胞，以及最近对大鼠视觉皮层的免疫组织化学和电生理学观察，以及髓鞘形成过程的相互调节，支持了 SWM 巢状的皮质下、区域可变、分布式神经元-神经胶质回路的可能性，这些回路可能会影响信息传递。应该考虑并通过实验分析它们在调节 SWM 轴突成分的时间和信号传递概率方面的假设性作用。因此，与局部胶质细胞相关的“间质”神经元细胞——在正常情况下被认为是残余的和功能上惰性的——它们可能在调节 SWM 中的信息传递方面变得至关重要。
