Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
First Affiliated Hospital of Jiamusi University, Jiamusi University, Jiamusi, China.
Cell Tissue Res. 2018 Apr;372(1):13-22. doi: 10.1007/s00441-017-2772-z. Epub 2018 Jan 24.
There are many factors to consider in the field of tissue engineering. For articular cartilage repair, this includes seed cells, scaffolds and chondrotrophic hormones. This review primarily focuses on the seed cells and scaffolds. Extracellular matrix proteins provide a natural scaffold for cell attachment, proliferation and differentiation. The structure and composition of tissue-derived scaffolds and native tissue are almost identical. As such, tissue-derived scaffolds hold great promise for biomedical applications. However, autologous tissue-derived scaffolds also have many drawbacks for transplantation, as harvesting autografts is limited to available donor sites and requires secondary surgery, therefore imparting additional damage to the body. This review summarizes and analyzes various cell sources and tissue-derived scaffolds applied in orthopedic tissue engineering.
组织工程领域有许多因素需要考虑。对于关节软骨修复，这包括种子细胞、支架和软骨营养激素。本综述主要关注种子细胞和支架。细胞外基质蛋白为细胞附着、增殖和分化提供了天然支架。组织衍生支架的结构和组成与天然组织几乎相同。因此，组织衍生支架在生物医学应用中具有广阔的前景。然而，自体组织衍生支架在移植方面也有许多缺点，因为自体移植物的采集仅限于可用的供体部位，并且需要二次手术，因此会给身体带来额外的损伤。本综述总结和分析了应用于骨科组织工程的各种细胞来源和组织衍生支架。
