Department of Traumatic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Human Anatomy, Histology and Embryology, College of Medicine, Qingdao University, Qingdao, 266021, China.
Macromol Biosci. 2020 Feb;20(2):e1900278. doi: 10.1002/mabi.201900278. Epub 2019 Dec 4.
Repair and regeneration of articular cartilage lesions have always been a major challenge in the medical field due to its peculiar structure (e.g., sparsely distributed chondrocytes, no blood supply, no nerves). Articular cartilage tissue engineering is considered as one promising strategy to achieve reconstruction of cartilage. With this perspective, the articular cartilage tissue engineering has been widely studied. Here, the recent progress of articular cartilage tissue engineering is reviewed. The ad hoc therapeutic cells and growth factors for cartilage regeneration are summarized and discussed. Various types of bio/macromolecular scaffolds together with their pros and cons are also reviewed and elaborated.
关节软骨损伤的修复和再生一直是医学领域的一大挑战，这是由于其特殊的结构（例如，软骨细胞分布稀疏、无血液供应、无神经）所致。关节软骨组织工程被认为是实现软骨重建的一种有前途的策略。从这个角度来看，关节软骨组织工程已经得到了广泛的研究。本文综述了关节软骨组织工程的最新进展。总结和讨论了用于软骨再生的特定治疗细胞和生长因子。还回顾和阐述了各种类型的生物/高分子支架及其优缺点。
