From the Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Anesthesiology and Intensive Care Medicine, University of Lübeck, Lübeck, Germany.
Anesth Analg. 2019 Feb;128(2):265-277. doi: 10.1213/ANE.0000000000002812.
Maintaining brain function and integrity is a pivotal part of anesthesiological practice. The present overview aims to describe the current role of the 2 most frequently used monitoring methods for evaluation brain function in the perioperative period, ie, electroencephalography (EEG) and brain oxygenation monitoring. Available evidence suggests that EEG-derived parameters give additional information about depth of anesthesia for optimizing anesthetic titration. The effects on reduction of drug consumption or recovery time are heterogeneous, but most studies show a reduction of recovery times if anesthesia is titrated along processed EEG. It has been hypothesized that future EEG-derived indices will allow a better understanding of the neurophysiological principles of anesthetic-induced alteration of consciousness instead of the probabilistic approach most often used nowadays.Brain oxygenation can be either measured directly in brain parenchyma via a surgical burr hole, estimated from the venous outflow of the brain via a catheter in the jugular bulb, or assessed noninvasively by near-infrared spectroscopy. The latter method has increasingly been accepted clinically due to its ease of use and increasing evidence that near-infrared spectroscopy-derived cerebral oxygen saturation levels are associated with neurological and/or general perioperative complications and increased mortality. Furthermore, a goal-directed strategy aiming to avoid cerebral desaturations might help to reduce these complications. Recent evidence points out that this technology may additionally be used to assess autoregulation of cerebral blood flow and thereby help to titrate arterial blood pressure to the individual needs and for bedside diagnosis of disturbed autoregulation.
维持大脑功能和完整性是麻醉学实践的关键部分。本综述旨在描述在围手术期评估脑功能时最常使用的两种监测方法,即脑电图(EEG)和脑氧合监测的当前作用。现有证据表明,EEG 衍生参数可提供有关麻醉深度的额外信息,以优化麻醉滴定。对减少药物消耗或恢复时间的影响是不均匀的,但大多数研究表明,如果根据处理后的 EEG 滴定麻醉,恢复时间会缩短。有人假设,未来的 EEG 衍生指数将允许更好地理解麻醉诱导意识改变的神经生理原理,而不是目前常用的概率方法。脑氧合可以通过手术颅骨钻孔直接测量脑实质中的氧合,也可以通过颈静脉球中的导管从脑静脉流出估计氧合,或者通过近红外光谱无创评估。由于其易于使用以及越来越多的证据表明,近红外光谱衍生的脑氧饱和度水平与神经和/或一般围手术期并发症以及死亡率增加相关,因此这种方法在临床上越来越被接受。此外,旨在避免脑饱和度降低的目标导向策略可能有助于减少这些并发症。最近的证据表明,该技术还可用于评估脑血流自动调节,从而有助于根据个体需要滴定动脉血压,并进行床边诊断自动调节障碍。