Dermatology Department, CIC 1413, CRCINA Inserm 1232, CHU Nantes, Nantes, France.
Bacteriology Department, CRCINA Inserm 1232, CHU Nantes, Nantes, France.
Int J Dermatol. 2018 Mar;57(3):278-283. doi: 10.1111/ijd.13910. Epub 2018 Jan 25.
Acne is an inflammatory disease of the pilosebaceous follicle, affecting 41-54% of adult women, with a particular form that involves the mandible.
We characterized infundibulum morphology in two groups of adult women using reflectance confocal microscopy. First, we investigated acne visually "healthy zones" on the forehead in 15 adult women with diffuse acne and compared with acne-free controls. We then compared healthy forehead and affected mandibular zone in 15 acne patients with mandibular involvement. Exposed results had a P < 0.05.
Seven hundred and ninety-one follicles were observed on apparently healthy skin of 15 adult women with acne, with a larger diameter, thicker (68%), and hyper keratinized (65%) follicle border, and more keratin plugs (44%) than in controls. In the second group of 15 adult women with mandibular acne, we compared 569 follicles in the mandibular zone and 475 on forehead. In the mandibular area, follicles were significantly larger, thicker (76%), more hyper keratinized (72%), with more keratin plugs (47%) and increased inflammation (23%) compared with the forehead area. In the mandibular area, 0.2% of follicles showed isolated inflammation without hyper keratinization, and 15.3% had both thickened borders with an onion-like appearance and keratin plugs associated with inflammation.
Hyper keratinization was higher in healthy skin of adult women with acne compared with controls, confirming that microcomedo is crucial in the development of acne lesions. We also demonstrate that the repartition of comedones and microcomedones is inhomogeneous with a great number in the mandibular area where acne lesions are located.
痤疮是一种毛囊皮脂腺的炎症性疾病，影响 41-54%的成年女性，其中有一种特殊的形式涉及下颌。
我们使用反射共聚焦显微镜对两组成年女性的漏斗部形态进行了特征描述。首先，我们研究了 15 名患有弥漫性痤疮的成年女性额头上肉眼可见的“健康区域”，并与无痤疮的对照组进行了比较。然后，我们比较了 15 名下颌部有痤疮患者的健康额部和受累下颌部。暴露结果的 P 值<0.05。
在 15 名患有痤疮的成年女性的看似健康的皮肤上观察到 791 个毛囊，这些毛囊的直径更大，毛囊边缘更厚（68%）、过度角化（65%），并且有更多的角蛋白栓（44%），与对照组相比。在第二组 15 名下颌部有痤疮的成年女性中，我们比较了下颌部的 569 个毛囊和额部的 475 个毛囊。在下颌部，毛囊明显更大，更厚（76%），过度角化（72%）更多，角蛋白栓（47%）更多，炎症（23%）增加，与额部相比。在下颌部，0.2%的毛囊仅表现为孤立性炎症而无过度角化，15.3%的毛囊表现为洋葱样增厚的边界和伴有炎症的角蛋白栓。
与对照组相比，患有痤疮的成年女性健康皮肤中的过度角化程度更高，这证实了微粉刺在痤疮皮损的发展中至关重要。我们还表明，粉刺和微粉刺的分布是不均匀的，下颌部有大量的粉刺，而痤疮病变就位于下颌部。
