心钠素与大鼠自发性高血压

Atriopeptin and spontaneous hypertension in rats.

作者信息

Xie C W, Song D L, Ding J F, Chang J K, Chang D, Tang J

出版信息

Life Sci. 1986 Mar 17;38(11):1035-9. doi: 10.1016/0024-3205(86)90238-9.

Abstract

The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affected. The contents of atriopeptin immunoreactive material in the rat atrium and plasma were measured with radioimmunoassay. Both the atrium and plasma contents of atriopeptin immunoreactive material were found to be significantly higher in SHR than in the normotensive control Wistar Kyoto (WKY), indicating an increase in the biosynthesis and release of atriopeptin in SHR. Whether this change was a compensatory response induced by hypertension remains to be investigated.

摘要

在自发性高血压大鼠（SHR）中研究了心钠素在高血压中的作用。发现静脉注射心钠素III（20 - 80 nmol/kg）能以剂量依赖的方式显著降低麻醉的SHR的平均动脉压。心率未受到明显影响。用放射免疫分析法测定大鼠心房和血浆中心钠素免疫反应性物质的含量。发现SHR中心钠素免疫反应性物质的心房和血浆含量均显著高于正常血压对照Wistar Kyoto（WKY）大鼠，表明SHR中心钠素的生物合成和释放增加。这种变化是否是由高血压诱导的代偿性反应仍有待研究。