Goyot C, Debray Q, Dugas M, Guay C, Giraud J, Grenier J
Pathol Biol (Paris). 1985 Dec;33(10):999-1004.
Therapeutic plasma monitoring of haloperidol, a major neuroleptic, measured by radioimmunoassay, has shown a rather good correlation between plasma level and dosage but with large interindividual variation in children as in adults; age seems not to have any effect on haloperidol metabolism. 80% of subjects present a concomitant prolactin levels variation, whereas in 20% no prolactin response is found. During acute kinetics of either a 10 mg oral haloperidol administration or a 250 mg intramuscular haloperidol decanoate injection, a parallel elevation of prolactin, cortisol, immunoreactive bêta-endorphin and bêta-lipotropin plasma levels occur, at the same time as haloperidol plasma levels. Those rise with a good equivalence between the two doses of the two forms.
通过放射免疫分析法对主要抗精神病药物氟哌啶醇进行治疗性血浆监测，结果表明血浆水平与剂量之间存在较好的相关性，但儿童和成人一样，个体间差异较大；年龄似乎对氟哌啶醇的代谢没有任何影响。80%的受试者催乳素水平会同时发生变化，而20%的受试者未发现催乳素反应。在口服10mg氟哌啶醇或注射250mg癸酸氟哌啶醇的急性动力学过程中，催乳素、皮质醇、免疫反应性β-内啡肽和β-促脂素的血浆水平与氟哌啶醇血浆水平同时平行升高。两种剂型的两种剂量之间具有良好的等效性。
