Dugas M, Zarifian E, Le Heuzey M F, Regnier N, Durand G, Bianchetti G, Morselli P L
Nouv Presse Med. 1982 Jun 19;11(29):2201-4.
Monitoring of haloperidol plasma levels during long-term treatment is not commonly practised in adults and even less in children. In this study, haloperidol plasma levels were measured in children and teenagers with psychotic episodes or abnormal movements. Steady state concentrations ranged from 0.7 to 19 ng/ml. They were apparently unrelated to the doses administered (15-285 micrograms/kg/day), and variations of up to 15-fold were observed with the same dosage. In contrast, a significant correlation (p less than 0.02) was determined between age and dose-concentration ratio. Side-effects also seemed to be significantly related to plasma levels (p less than 0.01); they occurred at concentration higher than 6 ng/ml. Therapeutic response was observed with plasma concentrations of 1 to 4 ng/ml in cases with abnormal movements, but no dose-effect relationship was found in patients with psychotic episodes.
在成人中长期治疗期间监测氟哌啶醇血浆水平并不常见，在儿童中更是少见。在本研究中，对患有精神病性发作或异常运动的儿童和青少年测量了氟哌啶醇血浆水平。稳态浓度范围为0.7至19纳克/毫升。它们显然与给药剂量（15 - 285微克/千克/天）无关，并且在相同剂量下观察到高达15倍的变化。相比之下，年龄与剂量 - 浓度比之间存在显著相关性（p小于0.02）。副作用似乎也与血浆水平显著相关（p小于0.01）；它们发生在浓度高于6纳克/毫升时。在有异常运动的病例中，血浆浓度为1至4纳克/毫升时观察到治疗反应，但在患有精神病性发作的患者中未发现剂量 - 效应关系。
