Stougaard Maria, Damm Peter, Frederiksen Peder, Jacobsen Ramune, Heitmann Berit Lilienthal
Research Unit for Dietary Studies at the Parker Institute and Department of Clinical Epidemiology, Bispebjerg og Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Department of Obstetrics, Rigshospitalet and Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
PLoS One. 2018 Jan 25;13(1):e0191288. doi: 10.1371/journal.pone.0191288. eCollection 2018.
The objective of the study was to examine if exposure to extra vitamin D from food fortification was associated with a decrease in the risk of preeclampsia. The study was based on a natural experiment exploring the effect of the abolition of the Danish mandatory vitamin D fortification of margarine in 1985. The effect of the extra vitamin D (1.25μg vitamin D/100 g margarine) was examined by comparing preeclampsia risk in women who have been exposed or unexposed to extra vitamin D from the fortified margarine during pregnancy, and who gave birth in the period from June 1983 to August 1988. The Danish National Patient Registry allowed the identification of pregnancies complicated by preeclampsia. The study included 73,237 women who gave birth during 1983-1988. We found no association between exposure to vitamin D fortification during pregnancy and the risk of any of the pregnancy related hypertensive disorders, including preeclampsia: Odds ratios (OR, 95%) for all hypertensive pregnancy related disorders among exposed vs. unexposed women was (OR 1.04, 95%CI: 0.98,1.10). In conclusion, the extra vitamin D from the mandatory vitamin D fortification did not influence the risk of preeclampsia.
该研究的目的是检验从食物强化中摄入额外的维生素D是否与子痫前期风险降低相关。该研究基于一项自然实验，探究1985年丹麦废除人造黄油强制维生素D强化的影响。通过比较孕期接触或未接触强化人造黄油中额外维生素D、且于1983年6月至1988年8月期间分娩的女性的子痫前期风险，来研究额外维生素D（1.25μg维生素D/100g人造黄油）的作用。丹麦国家患者登记处可识别出并发子痫前期的妊娠情况。该研究纳入了1983 - 1988年期间分娩的73237名女性。我们发现孕期接触维生素D强化与包括子痫前期在内的任何妊娠相关高血压疾病风险之间无关联：接触组与未接触组女性中所有妊娠相关高血压疾病的比值比（OR，95%）为（OR 1.04，95%CI：0.98，1.10）。总之，强制维生素D强化中额外的维生素D并未影响子痫前期风险。
