Andreu Catherine I, Cosmelli Diego, Slagter Heleen A, Franken Ingmar H A
Escuela de Psicología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Millennium Institute for Research in Depression and Personality (MIDAP), Santiago, Chile.
PLoS One. 2018 Jan 25;13(1):e0191661. doi: 10.1371/journal.pone.0191661. eCollection 2018.
Research suggests that mindfulness-practices may aid smoking cessation. Yet, the neural mechanisms underlying the effects of mindfulness-practices on smoking are unclear. Response inhibition is a main deficit in addiction, is associated with relapse, and could therefore be a candidate target for mindfulness-based practices. The current study hence investigated the effects of a brief mindfulness-practice on response inhibition in smokers using behavioral and electroencephalography (EEG) measures. Fifty participants (33 females, mean age 20 years old) underwent a protocol of cigarette exposure to induce craving (cue-exposure) and were then randomly assigned to a group receiving mindfulness-instructions or control-instructions (for 15 minutes approximately). Immediately after this, they performed a smoking Go/NoGo task, while their brain activity was recorded. At the behavioral level, no group differences were observed. However, EEG analyses revealed a decrease in P3 amplitude during NoGo vs. Go trials in the mindfulness versus control group. The lower P3 amplitude might indicate less-effortful response inhibition after the mindfulness-practice, and suggest that enhanced response inhibition underlies observed positive effects of mindfulness on smoking behavior.
研究表明，正念练习可能有助于戒烟。然而，正念练习对吸烟影响的神经机制尚不清楚。反应抑制是成瘾的主要缺陷，与复吸有关，因此可能是基于正念练习的一个潜在目标。因此，本研究使用行为和脑电图（EEG）测量方法，调查了简短的正念练习对吸烟者反应抑制的影响。50名参与者（33名女性，平均年龄20岁）接受了香烟暴露方案以诱发渴望（线索暴露），然后被随机分配到接受正念指导或对照指导的组（约15分钟）。在此之后，他们立即进行了吸烟“是/否”任务，同时记录他们的大脑活动。在行为水平上，未观察到组间差异。然而，脑电图分析显示，与对照组相比，正念组在“否”试验与“是”试验期间P3波幅降低。较低的P3波幅可能表明正念练习后反应抑制的努力程度降低，并表明反应抑制增强是正念对吸烟行为观察到的积极影响的基础。
