Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Division of Pediatric and Adolescent Gynecology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Cancer. 2018 May 1;124(9):1867-1876. doi: 10.1002/cncr.31255. Epub 2018 Jan 25.
The incidence of childhood cancer has steadily increased since the 1950s, with approximately 16,000 children diagnosed each year. However, with the advent of more effective multimodal therapies, childhood cancer survival rates have continued to improve over the past 40 years, with >80% of patients now surviving into adulthood. Fertility preservation (FP) has become an important quality-of-life issue for many survivors of childhood cancer. As a result, the therapeutic options have become less gonadotoxic over time and more patients are being offered FP options. This review examines the indications for consultation, male and female FP options both in the prepubertal patient and adolescent patient, and the unique ethical issues surrounding FP in this vulnerable population. Cancer 2018;124:1867-76. © 2018 American Cancer Society.
自 20 世纪 50 年代以来，儿童癌症的发病率稳步上升，每年约有 16000 名儿童被诊断出患有癌症。然而，随着更有效的多模式治疗方法的出现，过去 40 年来，儿童癌症的存活率继续提高，现在超过 80%的患者能够存活到成年。生育力保存（FP）已成为许多儿童癌症幸存者生活质量的一个重要问题。因此，随着时间的推移，治疗选择的性腺毒性越来越小，越来越多的患者被提供 FP 选择。这篇综述检查了咨询的适应症，包括在青春期前患者和青少年患者中男性和女性 FP 的选择，以及围绕这一脆弱人群 FP 的独特伦理问题。癌症 2018；124:1867-76. © 2018 美国癌症协会。
