Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea.
J Clin Hypertens (Greenwich). 2018 Mar;20(3):462-468. doi: 10.1111/jch.13200. Epub 2018 Jan 25.
Although brachial-ankle pulse wave velocity (baPWV) has been widely used as an index of arterial stiffness, no consensus exists about whether baPWV can reflect central aortic stiffness. The authors investigated the association between baPWV and invasively measured aortic pulse pressure (APP) in a total of 109 consecutive patients (mean age, 62.3 ± 11.3 years; 67.9% men). Most patients (91%) had obstructive coronary artery disease, and mean baPWV and APP values were 1535 ± 303 cm/s and 66.8 ± 22.5 mm Hg, respectively. In univariate analysis, there was a significant linear correlation between baPWV and APP (r = .635, P < .001). The correlation between baPWV and APP remained significant even after controlling for potential confounders (β = 0.574, P < .001; R = .469). Arterial stiffness measured by baPWV showed a strong positive correlation with invasively measured APP, independent of clinical confounders. Therefore, baPWV can be a good marker of central aortic stiffness.
尽管肱踝脉搏波速度（baPWV）已被广泛用作动脉僵硬的指标，但对于它是否能反映主动脉中心僵硬程度，尚无共识。作者共纳入了 109 例连续患者（平均年龄 62.3±11.3 岁；67.9%为男性），研究了 baPWV 与侵入性测量的主动脉脉搏压（APP）之间的相关性。大多数患者（91%）患有阻塞性冠状动脉疾病，平均 baPWV 和 APP 值分别为 1535±303cm/s 和 66.8±22.5mmHg。在单因素分析中，baPWV 与 APP 之间存在显著的线性相关性（r=.635，P<0.001）。即使在控制了潜在混杂因素后，baPWV 与 APP 之间的相关性仍然显著（β=0.574，P<0.001；R=0.469）。baPWV 测量的动脉僵硬与侵入性测量的 APP 呈强正相关，独立于临床混杂因素。因此，baPWV 可以作为中心主动脉僵硬的一个良好标志物。
