Severance Biomedical Science Institute & Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Mol Cells. 2018 Jan 31;41(1):11-17. doi: 10.14348/molcells.2018.2228. Epub 2018 Jan 23.
Autophagy is critical for the maintenance of organelle function and intracellular nutrient environment. Autophagy is also involved in systemic metabolic homeostasis, and its dysregulation can lead to or accelerate the development of metabolic disorders. While the role of autophagy in the global metabolism of model organisms has been investigated mostly using site-specific genetic knockout technology, the impact of dysregulated autophagy on systemic metabolism has been unclear. Here, we review recent papers showing the role of autophagy in systemic metabolism and in the development of metabolic disorders. Also included are data suggesting the role of autophagy in human-type diabetes, which are different in several key aspects from murine models of diabetes. The results shown here support the view that autophagy modulation could be a new modality for the treatment of metabolic syndrome associated with lipid overload and human-type diabetes.
自噬对于细胞器功能和细胞内营养环境的维持至关重要。自噬也参与全身代谢稳态，其失调可导致或加速代谢紊乱的发展。虽然自噬在模式生物的整体代谢中的作用主要是使用特定部位的遗传敲除技术来研究的，但自噬失调对全身代谢的影响尚不清楚。在这里，我们综述了最近的一些论文，这些论文展示了自噬在全身代谢和代谢紊乱发展中的作用。还包括一些数据表明自噬在人类型糖尿病中的作用，这些数据在几个关键方面与糖尿病的鼠模型不同。这里显示的结果支持这样一种观点，即自噬调节可能是治疗与脂质过载和人类型糖尿病相关的代谢综合征的一种新方法。
