Biasato Ilaria, Biasibetti Elena, Biagini Davide, Bruatto Guido, Cenacchi Giovanna, Guarda Franco, Capucchio Maria Teresa
Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, Grugliasco 10095, Turin, Italy.
Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, Grugliasco 10095, Turin, Italy.
J Vet Cardiol. 2018 Feb;20(1):55-63. doi: 10.1016/j.jvc.2017.12.001. Epub 2018 Jan 20.
Intramural coronary arteriosclerosis has been reported in several species, but no systematic studies are currently available in bovine. The present study aimed to describe the arteriosclerotic changes in regularly slaughtered veal calves and beef cattle.
Twenty-five veal calves (6-9 months old) and 17 beef cattle (10-24 months old) housed in intensive livestock farming and regularly slaughtered were included in the present study.
Selected heart samples were submitted for histopathological and ultrastructural examination and the following parameters were evaluated: intimal hyperplasia, degenerative changes of the tunica media, medial hypertrophy/hyperplasia, myocardial fibrosis, and myocarditis. Pathological intramural coronary arteries with and without lumen narrowing were manually counted in every sample.
Intramural coronary arteriosclerosis was observed in all the calves and cattle, with similar prevalence of fibromuscular/muscular intimal hyperplasia (92% vs 88%), degenerative changes of the tunica media (76% vs 71%), and medial hypertrophy/hyperplasia (44% vs 59%). The posterior papillary muscle of the left ventricle was the myocardial localization significantly more affected in both calves (p = 0.0007) and cattle (p = 0.0339). Anitschkow cells were detected in the coronary walls of both calves (60%) and cattle (76%).
This is the first study that systematically describes spontaneously occurring intramural coronary arteriosclerosis in bovine species. Anitschkow cells, whose ultrastructural characteristics and localization suggest their potential origin from the smooth muscle cells of the tunica media of the arteriosclerotic coronary vessels, were also identified.
已有报道在多个物种中发现壁内冠状动脉硬化，但目前尚无关于牛的系统性研究。本研究旨在描述定期屠宰的犊牛和肉牛的动脉硬化变化。
本研究纳入了25头集约化养殖且定期屠宰的犊牛（6 - 9月龄）和17头肉牛（10 - 24月龄）。
选取心脏样本进行组织病理学和超微结构检查，并评估以下参数：内膜增生、中膜退行性改变、中膜肥厚/增生、心肌纤维化和心肌炎。对每个样本中有无管腔狭窄的病理性壁内冠状动脉进行人工计数。
在所有犊牛和肉牛中均观察到壁内冠状动脉硬化，纤维肌性/肌性内膜增生的发生率相似（92%对88%），中膜退行性改变的发生率相似（76%对71%），中膜肥厚/增生的发生率相似（44%对59%）。左心室后乳头肌是犊牛（p = 0.0007）和肉牛（p = 0.0339）中心肌受影响显著更严重的部位。在犊牛（60%）和肉牛（76%）的冠状动脉壁中均检测到阿绍夫细胞。
这是第一项系统描述牛自发发生的壁内冠状动脉硬化的研究。还鉴定出了阿绍夫细胞，其超微结构特征和定位表明它们可能起源于动脉硬化冠状动脉中膜的平滑肌细胞。
