Wälti M, Neftel K A, Jost R, Jaeger A, Berg P, Heinzel F, Weitzel M
Schweiz Med Wochenschr. 1986 Jan 25;116(4):98-103.
During treatment with flavonoid drugs a number of patients developed adverse reactions such as fever, various skin eruptions and intravascular hemolysis. The appearance of flavonoid-specific IgE and IgG antibodies and its possible relation to the observed side effects was studied on a total of 168 individuals treated with flavonoid drugs: 71 patients received troxerutin (Venoruton) parenterally to improve tolerance of radiation therapy, 12 patients were treated intravenously with silymarin (Legalon) for amanita intoxication and 77 patients received various flavonoid drugs for other indications. Flavonoid treatment often induced specific IgG antibodies and less frequently IgE antibodies. After short treatment IgE antibodies were more frequently detected than after treatment of longer duration which nearly always induced IgG antibodies. Patients with hemolysis had the highest IgG titers. In cases with fever and skin eruptions no correlation with antibody titers became evident. Antibody production in patients undergoing radiation therapy appeared to be lower than in non-irradiated patients. Both the IgE and IgG antibody test show a remarkable cross-reactivity between four different flavonoids. Prospective studies will be necessary to decide whether or not this method for the detection of anti-flavonoid antibodies will be suitable for recognizing increased risk of side reactions upon reexposure to flavonoid drugs.
在使用类黄酮药物治疗期间，一些患者出现了不良反应，如发热、各种皮疹和血管内溶血。对总共168例接受类黄酮药物治疗的个体进行了研究，观察类黄酮特异性IgE和IgG抗体的出现情况及其与观察到的副作用的可能关系：71例患者接受曲克芦丁（维脑路通）肠外给药以提高放疗耐受性，12例患者静脉注射水飞蓟宾（利加隆）治疗鹅膏菌中毒，77例患者因其他适应症接受各种类黄酮药物治疗。类黄酮治疗常诱导产生特异性IgG抗体，较少诱导产生IgE抗体。短疗程治疗后比长疗程治疗后更频繁地检测到IgE抗体，长疗程治疗几乎总是诱导产生IgG抗体。溶血患者的IgG滴度最高。在发热和皮疹病例中，未发现与抗体滴度有明显相关性。接受放疗的患者的抗体产生似乎低于未接受放疗的患者。IgE和IgG抗体检测均显示四种不同类黄酮之间有显著的交叉反应性。需要进行前瞻性研究，以确定这种检测抗类黄酮抗体的方法是否适用于识别再次接触类黄酮药物时副作用风险增加的情况。
