Wadi Jamal, Denning David W
The Medical Center, Jordan Hospital and Medical Center, 29 Adeeb Wahbeh Street, 11118 Amman, Jordan.
Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M23 9LT, UK.
J Fungi (Basel). 2018 Jan 18;4(1):15. doi: 10.3390/jof4010015.
To estimate the burden of fungal infections in Jordan for the first time.
Population data was from UN 2011 statistics and TB cases from WHO in 2012. Fewer than 100 patients with HIV were recorded in Jordan in 2013. Approximately 100 renal transplants and eight liver transplants are performed annually. There were 12,233 major surgical procedures in Jordan in 2013, of which 5.3% were major abdominal surgeries; candidemia was estimated in 5% of the population based on other countries, with 33% occurring in the ICU. peritonitis/intra-abdominal candidiasis was estimated to affect 50% of the number of ICU candidemia cases. No adult asthma rates have been recorded for Jordan, so the rate from the Holy Land (8.54% clinical asthma) from To et al. has been used. There are an estimated 49,607 chronic obstructive pulmonary disease (COPD) patients in Jordan, with 64% symptomatic, 25% Gold stage 3% or 4%, and 7% (3472) are assumed to be admitted to hospital each year. No cystic fibrosis cases have been recorded. Literature searches on fungal infections revealed few data and no prevalence data on fungal keratitis or tinea capitis, even though tinea capitis comprised 34% of patients with dermatophytoses in Jordan.
Jordan has 6.3 million inhabitants (65% adults, 6% are >60 years old). The current burden of serious fungal infections in Jordan was estimated to affect ~119,000 patients (1.9%), not including any cutaneous fungal infections. Candidemia was estimated at 316 cases and invasive aspergillosis in leukemia, transplant, and COPD patients at 84 cases. Chronic pulmonary aspergillosis prevalence was estimated to affect 36 post-TB patients, and 175 in total. Allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS) prevalence in adults with asthma were estimated at 8900 and 11,748 patients. Recurrent vulvovaginal candidiasis was estimated to affect 97,804 patients, using a 6% rate among women 15-50 years of age.
Based on local data and literature estimates of the frequency of mycoses in susceptible populations, at least 1.9% of Jordanians have some form of serious fungal disease.
首次评估约旦真菌感染的负担。
人口数据来自联合国2011年统计数据，结核病病例来自世界卫生组织2012年的数据。2013年约旦记录的艾滋病毒患者少于100例。每年约进行100例肾移植和8例肝移植。2013年约旦有12233例大手术，其中5.3%为腹部大手术；根据其他国家情况估计，5%的人群发生念珠菌血症，其中33%发生在重症监护病房（ICU）。腹膜炎/腹腔内念珠菌病估计影响ICU念珠菌血症病例数的50%。约旦没有记录成人哮喘发病率，因此采用了To等人报道的圣地地区的发病率（临床哮喘发病率为8.54%）。约旦估计有49607例慢性阻塞性肺疾病（COPD）患者，其中64%有症状，25%为金氏3级或4级，每年估计有7%（3472例）住院治疗。没有记录囊性纤维化病例。关于真菌感染的文献检索显示数据很少，甚至没有关于真菌性角膜炎或头癣的患病率数据，尽管头癣占约旦皮肤癣菌病患者的34%。
约旦有630万居民（65%为成年人，6%年龄超过60岁）。据估计，约旦目前严重真菌感染的负担影响约119000名患者（1.9%），不包括任何皮肤真菌感染。念珠菌血症估计有316例，白血病、移植和COPD患者的侵袭性曲霉病有84例。慢性肺曲霉病患病率估计影响36例结核病后患者，总共175例。哮喘成人中变应性支气管肺曲霉病（ABPA）和真菌致敏重度哮喘（SAFS）的患病率估计分别为8900例和11748例。采用15 - 50岁女性6%的发病率，复发性外阴阴道念珠菌病估计影响97804例患者。
根据当地数据和文献对易感人群中真菌病发病率的估计，至少1.9%的约旦人患有某种形式的严重真菌病。
