Yumioka Tetsuya, Honda Masashi, Kimura Yusuke, Yamaguchi Noriya, Iwamoto Hideto, Morizane Shuichi, Hikita Katsuya, Takenaka Atsushi
Department of Urology Tottori University Faculty of Medicine Yonago Japan.
Reprod Med Biol. 2017 Oct 10;17(1):36-43. doi: 10.1002/rmb2.12063. eCollection 2018 Jan.
To evaluate in Japanese patients their sexual function after robot-assisted radical prostatectomy (RARP) and to investigate the influence of the multinerve-sparing (NS) grade on their sexual function.
In total, 225 patients were reviewed with localized prostate cancer who underwent RARP at the authors' institution. They underwent RARP >3 months ago, without pre- and posthormone therapy and salvage radiation. Self-administered International Index of Erectile Function (IIEF) questionnaires were used for assessment preoperatively and 1-48 months postoperatively. In all, 129 patients were evaluated with the preoperative IIEF-Question 1 and who achieved a score of ≥2 by being divided into five NS groups. The recovery rates of erection (postoperative IIEF-Question 1 score of ≥2) were calculated by using the Kaplan-Meier analysis.
Seventy-four percent of all the patients had not attempted sexual intercourse, but 60% had felt sexual desire at 24 months postoperatively. In those patients with a preoperative erection, the recovery rate of erection was 58% at 24 months after the RARP. Across the five NS groups, as the procedure was more nerve-sparing, the recovery rate of erection became significantly higher. The postoperative effects on erection in the bilateral and unilateral NS groups were significantly superior to those in the other NS groups.
In Japanese patients, erection after a RARP is improved with multiNS grade procedures.
评估日本患者机器人辅助根治性前列腺切除术(RARP)后的性功能,并研究多神经保留(NS)分级对其性功能的影响。
对在作者所在机构接受RARP的225例局限性前列腺癌患者进行回顾性研究。他们在3个月前接受了RARP,未接受术前和术后激素治疗及挽救性放疗。术前及术后1 - 48个月使用国际勃起功能指数(IIEF)自填问卷进行评估。共有129例患者通过术前IIEF问题1进行评估,并根据NS分级分为五组,得分≥2分。采用Kaplan - Meier分析计算勃起恢复率(术后IIEF问题1得分≥2)。
所有患者中有74%未尝试过性交,但60%在术后24个月时有性欲。在术前有勃起功能的患者中,RARP术后24个月勃起恢复率为58%。在五个NS组中,随着手术保留神经越多,勃起恢复率显著越高。双侧和单侧NS组术后对勃起的影响明显优于其他NS组。
在日本患者中,多NS分级手术可改善RARP后的勃起功能。