Son Kyung-A, Kim Minji, Kim Yoo Min, Kim Soo Hyun, Choi Suk-Joo, Oh Soo-Young, Roh Cheong-Rae, Kim Jong-Hwa
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Obstet Gynecol Sci. 2018 Jan;61(1):38-47. doi: 10.5468/ogs.2018.61.1.38. Epub 2017 Dec 26.
The aim of this study was to investigate the prevalence of abnormal vaginal microorganisms in pregnant women according to trimester, and to determine whether the presence of abnormal vaginal colonization is associated with higher risk of miscarriage or preterm delivery. Furthermore, we analyzed delivery outcomes according to individual microorganism species.
We included pregnant women who underwent vaginal culture during routine prenatal check-up between January 2011 and June 2016. We compared delivery outcomes according to the presence or absence of abnormal vaginal flora grouped by trimester.
This study included 593 singleton pregnancies. We classified participants into 3 groups, according to the trimester in which vaginal culture was performed; 1st trimester (n=221), 2nd trimester (n=138), and 3rd trimester (n=234). Abnormal vaginal colonization rate significantly decreased with advancing trimester of pregnancy (21.7% for 1st, 21.0% for 2nd, 14.5% for 3rd; =0.048). Abnormal vaginal colonization detected in the 2nd trimester but not in 1st trimester was associated with a significant increase in preterm delivery before 28 weeks of gestation (6.9% vs. 0%; =0.006). Among abnormal vaginal flora isolated in the 2nd trimester, the presence of was identified as significant microorganism associated with preterm delivery before 28 weeks of gestation (50% vs. 0.7% for ; =0.029).
There is an association between abnormal vaginal colonization detected in the 2nd trimester and preterm delivery before 28 weeks. has been identified as the likely causative microorganisms.
本研究旨在调查不同孕期孕妇阴道微生物异常的患病率，并确定阴道定植异常是否与流产或早产风险增加有关。此外，我们根据个体微生物种类分析了分娩结局。
我们纳入了2011年1月至2016年6月期间在常规产前检查时接受阴道培养的孕妇。我们根据孕期将阴道菌群异常与否分组，比较分娩结局。
本研究纳入了593例单胎妊娠。根据进行阴道培养的孕期，我们将参与者分为3组：孕早期（n = 221）、孕中期（n = 138）和孕晚期（n = 234）。随着孕期进展，阴道定植异常率显著降低（孕早期为21.7%，孕中期为21.0%，孕晚期为14.5%；P = 0.048）。孕中期检测到阴道定植异常但孕早期未检测到与妊娠28周前早产显著增加相关（6.9% 对0%；P = 0.006）。在孕中期分离出的异常阴道菌群中，已确定某种微生物的存在与妊娠28周前早产相关（该微生物为50% 对0.7%；P = 0.029）。
孕中期检测到的阴道定植异常与妊娠28周前早产之间存在关联。已确定某种微生物可能是致病微生物。
