Mendes Ana Carolina, Restrepo Manuel, Bussaneli Diego, Zuanon Angela Cristina
Oral Health Prev Dent. 2018;16(1):27-31. doi: 10.3290/j.ohpd.a39749.
To evaluate the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the remineralisation of white-spot lesions in 80 anterior teeth of children aged 5-13 years enrolled in public schools of the city of Botucatu, São Paulo, Brazil.
The study sample consisted of 36 individuals divided into 4 groups: G1. control (placebo paste); G2. fluoride gel; G3. CPP-ACP; G4: CPP-ACP + fluoride. Each product was applied twice by a calibrated examiner with a week of interval between. Lesions were monitored with a DIAGNOdent Pen before the first application, before the second application, and 1 and 3 months after the first application. To evaluate the lesion intensity, the Friedman test was applied, and to compare experimental groups, the Kruskal-Wallis test was applied. The analyses were complemented with the Dunn test and the level of significance was 5%.
At the end of the 90-day trial, the use of CPP-ACP and fluoride showed comparable results in terms of remineralisation. The best white-spot lesion remineralisation was observed when CPP-ACP and fluoride were combined.
The use of CPP-ACP is a good alternative for the remineralisation of white-spot lesions. The effect can be improved when this product is applied in combination with fluoride.
评估酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）对巴西圣保罗州博图卡图市公立学校5至13岁儿童80颗前牙白斑病变再矿化的疗效。
研究样本包括36名个体，分为4组：G1. 对照组（安慰剂糊剂）；G2. 氟凝胶；G3. CPP - ACP；G4：CPP - ACP + 氟化物。每种产品由经过校准的检查者涂抹两次，间隔一周。在第一次涂抹前、第二次涂抹前以及第一次涂抹后1个月和3个月，使用DIAGNOdent Pen监测病变情况。为评估病变强度，应用Friedman检验，为比较各实验组，应用Kruskal - Wallis检验。分析通过Dunn检验进行补充，显著性水平为5%。
在90天试验结束时，CPP - ACP和氟化物在再矿化方面显示出可比的结果。当CPP - ACP与氟化物联合使用时，观察到最佳的白斑病变再矿化效果。
使用CPP - ACP是白斑病变再矿化的良好替代方法。当该产品与氟化物联合应用时，效果可以得到改善。
