Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Retin Cases Brief Rep. 2020 Summer;14(3):218-220. doi: 10.1097/ICB.0000000000000703.
To report an unusual case of cryptococcal choroiditis and highlight the multimodal imaging findings, particularly the choriocapillaris flow voids using optical coherence tomography angiography.
Retrospective review of the clinical course of a single patient with cryptococcal choroiditis.
A 69-year-old man undergoing chemotherapy for T-cell prolymphocytic leukemia developed disseminated crytococcal neoformans infection. He developed bilateral cryptococcal choroiditis with multiple yellow-white choroidal lesion on fundoscopy in both eyes. Multimodal imaging of the choroidal lesions revealed flow voids at the level of the choriocapillaris on optical coherence tomography angiography that corresponded to hypocyanescent areas on indocyanine green angiography when registered and overlaid on the indocyanine green angiography images. The superficial and deep capillary plexuses were spared.
This case illustrates that optical coherence tomography angiography was useful in demonstrating that the cryptococcal choroidal lesions impaired choriocapillaris perfusion but spared the superficial and deep retinal plexuses.
报告一例罕见的隐球菌性脉络膜炎病例，并强调多模式成像的发现，特别是应用光相干断层扫描血管造影观察到的脉络膜毛细血管血流空影。
回顾性分析一名隐球菌性脉络膜炎患者的临床病程。
一名 69 岁男性因 T 细胞前淋巴细胞白血病接受化疗，出现播散性新生隐球菌感染。他双眼均出现双侧隐球菌性脉络膜炎，眼底镜检查可见多个黄色-白色脉络膜病变。脉络膜病变的多模态成像显示，光相干断层扫描血管造影在脉络膜毛细血管水平存在血流空影，当与吲哚菁绿血管造影图像进行配准和叠加时，这些区域在吲哚菁绿血管造影图像上呈现低荧光。浅层和深层毛细血管丛未受累。
该病例说明光相干断层扫描血管造影有助于显示隐球菌性脉络膜病变损害脉络膜毛细血管灌注，但未累及浅层和深层视网膜丛。
