Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Querétaro 76230, Mexico.
Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, Aguascalientes 20131, Mexico.
Int J Mol Sci. 2018 Jan 26;19(2):375. doi: 10.3390/ijms19020375.
This brief review of the neurological effects of growth hormone (GH) and gonadotropin-releasing hormone (GnRH) in the brain, particularly in the cerebral cortex, hypothalamus, hippocampus, cerebellum, spinal cord, neural retina, and brain tumors, summarizes recent information about their therapeutic potential as treatments for different neuropathologies and neurodegenerative processes. The effect of GH and GnRH (by independent administration) has been associated with beneficial impacts in patients with brain trauma and spinal cord injuries. Both GH and GnRH have demonstrated potent neurotrophic, neuroprotective, and neuroregenerative action. Positive behavioral and cognitive effects are also associated with GH and GnRH administration. Increasing evidence suggests the possibility of a multifactorial therapy that includes both GH and GnRH.
这篇简要综述了生长激素 (GH) 和促性腺激素释放激素 (GnRH) 在大脑中的神经作用，特别是在大脑皮层、下丘脑、海马体、小脑、脊髓、神经视网膜和脑肿瘤中的神经作用，总结了它们作为治疗不同神经病理学和神经退行性过程的治疗潜力的最新信息。GH 和 GnRH（单独给药）的作用与脑外伤和脊髓损伤患者的有益影响有关。GH 和 GnRH 都表现出强大的神经营养、神经保护和神经再生作用。GH 和 GnRH 给药还与积极的行为和认知影响有关。越来越多的证据表明，包括 GH 和 GnRH 在内的多因素治疗是可能的。
