Miller R M, Taylor D E, Ringrose B S
Ann R Coll Surg Engl. 1986 Mar;68(2):85-8.
The biotolerant and haemodynamic effects of three types of woven polyethylene terephthalate (Dacron) arterial prostheses were compared. Two of these were unmodified, one low, one high porosity; and the third was the latter type radiation graft copolymerized with 5% acrylic acid. The prostheses were implanted as aorto-aortic bypass grafts, in dogs, for periods ranging from three to seventeen months. The copolymerized prosthesis exhibited the smallest rise in circumferential elastance from the 'as supplied' state, as well as a significantly slower pulse wave velocity, a significantly thinner internal lining, and a markedly lower longitudinal impedance. Of the unmodified prostheses, the low porosity graft had a significantly greater circumferential elastance, the poorest handling characteristics, and a tendency for pseudo intimal detachment. It was concluded that, although there was little difference between the two unmodified prostheses, the low porosity one had little to recommend it for use in small calibre bypass grafting. Copolymerization with acrylic acid produced better haemotolerant and haemodynamic results as well as surface properties which appeared to discourage fibrin and platelet adherence, and promote a more complete and organised pseudointima.
比较了三种编织聚对苯二甲酸乙二酯（涤纶）人工血管的生物耐受性和血液动力学效应。其中两种未改性，一种低孔隙率，一种高孔隙率；第三种是后一种类型与5%丙烯酸进行辐射接枝共聚。将这些人工血管作为主动脉-主动脉旁路移植物植入犬体内，植入时间为3至17个月。共聚人工血管从“供货”状态起，周向弹性增加最小，脉搏波速度明显较慢，内膜明显较薄，纵向阻抗明显较低。在未改性的人工血管中，低孔隙率移植物的周向弹性明显更大，操作特性最差，并有假性内膜剥离的倾向。得出的结论是，尽管两种未改性的人工血管之间差异不大，但低孔隙率的人工血管在小口径旁路移植中几乎没有优势。与丙烯酸共聚产生了更好的血液耐受性和血液动力学结果，以及似乎能抑制纤维蛋白和血小板粘附并促进更完整、更有序的假性内膜形成的表面特性。
