König W, Pfeiffer P, Rauschen I, Knöller J, Schönfeld W, Theobald K
Arzneimittelforschung. 1985;35(12A):1953-7.
Recent studies presented evidence that subpopulations of lymphocytes, monocytes and eosinophils carry immunoglobulin (IgE)-specific membrane receptors which differ from the classical Fc epsilon-receptors on basophil granulocytes and mast cells. The analysis of IgE-receptor interactions with various cells has led to important insights as to the requirements of IgE-antibody regulations. In addition, the membrane biochemical mechanisms in the induction of mediator release became better understood. The expression of low affinity receptors on lymphocytes appears to by intimately involved in the generation of IgE enhancing and suppressive factors. In future, these molecules might be available for immunotherapy. A summary of the recent knowledge combined with our data is presented.
最近的研究表明，淋巴细胞、单核细胞和嗜酸性粒细胞亚群携带免疫球蛋白（IgE）特异性膜受体，这些受体不同于嗜碱性粒细胞和肥大细胞上的经典Fcε受体。对IgE受体与各种细胞相互作用的分析，使人们对IgE抗体调节的要求有了重要认识。此外，对介质释放诱导过程中的膜生化机制也有了更好的理解。淋巴细胞上低亲和力受体的表达似乎与IgE增强因子和抑制因子的产生密切相关。未来，这些分子可能可用于免疫治疗。本文将近期的知识与我们的数据进行了总结。
