5. 免疫球蛋白E、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞。

5. IgE, mast cells, basophils, and eosinophils.

作者信息

Prussin Calman, Metcalfe Dean D

机构信息

Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Building 10, Rm. 11C-205, 10 Center Drive, Bethesda, MD 20892, USA.

出版信息

J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S450-6. doi: 10.1016/j.jaci.2005.11.016.

DOI:10.1016/j.jaci.2005.11.016

PMID:16455345

Abstract

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to FcepsilonRI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.

摘要

免疫球蛋白E、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞是过敏性炎症的重要组成部分。针对环境中的过敏原合成的过敏原特异性免疫球蛋白E会固定在肥大细胞和嗜碱性粒细胞膜上的FcepsilonRI受体上。再次接触特定过敏原时，与受体结合的免疫球蛋白E分子聚集会导致产生介导过敏反应的介质。被吸引到介质释放部位的主要细胞是嗜酸性粒细胞。