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宿主来源的白三烯B对抵抗侵袭性肺曲霉病至关重要。

Host-Derived Leukotriene B Is Critical for Resistance against Invasive Pulmonary Aspergillosis.

作者信息

Caffrey-Carr Alayna K, Hilmer Kimberly M, Kowalski Caitlin H, Shepardson Kelly M, Temple Rachel M, Cramer Robert A, Obar Joshua J

机构信息

Department of Microbiology and Immunology, Montana State University, Bozeman, MT, United States.

Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.

出版信息

Front Immunol. 2018 Jan 11;8:1984. doi: 10.3389/fimmu.2017.01984. eCollection 2017.

DOI:10.3389/fimmu.2017.01984
PMID:29375586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5768911/
Abstract

is a mold that causes severe pulmonary infections. Our knowledge of how immune competent hosts maintain control of fungal infections while constantly being exposed to fungi is rapidly emerging. It is known that timely neutrophil recruitment to and activation in the lungs is critical to the host defense against development of invasive pulmonary aspergillosis, but the inflammatory sequelae necessary remains to be fully defined. Here, we show that 5-Lipoxygenase (5-LO) and Leukotriene B (LTB) are critical for leukocyte recruitment and resistance to pulmonary challenge in a fungal-strain-dependent manner. 5-LO activity was needed in radiosensitive cells for an optimal anti-fungal response and LTB production was at least partially dependent on myeloid-derived hypoxia inducible factor-1α. Overall, this study reveals a role for host-derived leukotriene synthesis in innate immunity to .

摘要

是一种可引发严重肺部感染的霉菌。我们对于免疫功能正常的宿主在持续接触真菌的情况下如何维持对真菌感染的控制的认识正在迅速增加。已知及时将中性粒细胞招募至肺部并使其在肺部激活对于宿主抵御侵袭性肺曲霉病的发展至关重要，但必要的炎症后遗症仍有待充分明确。在此，我们表明5-脂氧合酶（5-LO）和白三烯B（LTB）以真菌菌株依赖性方式对于白细胞招募和抵抗肺部感染至关重要。在放射敏感细胞中需要5-LO活性以实现最佳抗真菌反应，并且LTB的产生至少部分依赖于骨髓来源的缺氧诱导因子-1α。总体而言，本研究揭示了宿主来源的白三烯合成在对……的固有免疫中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/661e5cf27056/fimmu-08-01984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/a9d696a92b11/fimmu-08-01984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/6dbeb5cba03d/fimmu-08-01984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/7136263624b3/fimmu-08-01984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/f941829a754d/fimmu-08-01984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/0d5ca346ad08/fimmu-08-01984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/661e5cf27056/fimmu-08-01984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/a9d696a92b11/fimmu-08-01984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/6dbeb5cba03d/fimmu-08-01984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/7136263624b3/fimmu-08-01984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/f941829a754d/fimmu-08-01984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/0d5ca346ad08/fimmu-08-01984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b3/5768911/661e5cf27056/fimmu-08-01984-g006.jpg

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