巨噬细胞Toll样受体与Fc受体协同作用的分子机制
Molecular mechanisms of macrophage Toll-like receptor-Fc receptor synergy.
作者信息
Lennartz Michelle, Drake James
机构信息
Department of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY, 12008, USA.
Department of Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY, 12008, USA.
出版信息
F1000Res. 2018 Jan 8;7:21. doi: 10.12688/f1000research.12679.1. eCollection 2018.
Abstract
Macrophages (MØs) are a key cell type of both the innate and the adaptive immune response and can tailor their response to prevailing conditions. To sense the host's status, MØs employ two classes of receptors: Toll-like receptors (TLRs), which are sensors for pathogen-derived material, and Fcγ receptors (FcγRs) that are detectors of the adaptive immune response. How MØs integrate the input from these various sensors is not understood and is the focus of active study. Here, we review the recent literature on the molecular mechanisms of TLR and FcgR crosstalk and synergy, and discuss the implications of these findings. This overview suggests a multilayered mechanism of receptor synergy that allows the MØ to fine-tune its response to prevailing conditions and provides ideas for future investigation.
摘要
巨噬细胞（MØs）是先天性和适应性免疫反应的关键细胞类型，能够根据当前情况调整其反应。为了感知宿主的状态，MØs使用两类受体：Toll样受体（TLRs），它是病原体衍生物质的传感器；以及Fcγ受体（FcγRs），它是适应性免疫反应的探测器。MØs如何整合来自这些不同传感器的输入尚不清楚，这也是当前积极研究的重点。在这里，我们综述了关于TLR和FcγR相互作用及协同作用分子机制的最新文献，并讨论了这些发现的意义。这一概述提出了一种受体协同作用的多层机制，使MØ能够对当前情况进行微调反应，并为未来的研究提供思路。
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