视神经脊髓炎中的视网膜神经节细胞-内网状层和神经纤维层
Retinal ganglion cell-inner plexiform and nerve fiber layers in neuromyelitis optica.
作者信息
Hu Sai-Jing, Lu Pei-Rong
机构信息
Department of Ophthalmology, the First Affiliated Hospital of Suzhou University, Suzhou 215000, Jiangsu Province, China.
Department of Ophthalmology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
出版信息
Int J Ophthalmol. 2018 Jan 18;11(1):89-93. doi: 10.18240/ijo.2018.01.16. eCollection 2018.
AIM
To determine the thickness of the retinal ganglion cell-inner plexiform layer (GCIPL) and the retinal nerve fiber layer (RNFL) in patients with neuromyelitis optica (NMO).
METHODS
We conducted a cross-sectional study that included 30 NMO patients with a total of 60 eyes. Based on the presence or absence of optic neuritis (ON), subjects were divided into either the NMO-ON group (30 eyes) or the NMO-ON contra group (10 eyes). A detailed ophthalmologic examination was performed for each group; subsequently, the GCIPL and the RNFL were measured using high-definition optical coherence tomography (OCT).
RESULTS
In the NMO-ON group, the mean GCIPL thickness was 69.28±21.12 µm, the minimum GCIPL thickness was 66.02±10.02 µm, and the RNFL thickness were 109.33±11.23, 110.47±3.10, 64.92±12.71 and 71.21±50.22 µm in the superior, inferior, temporal and nasal quadrants, respectively. In the NMO-ON contra group, the mean GCIPL thickness was 85.12±17.09 µm, the minimum GCIPL thickness was 25.39±25.1 µm, and the RNFL thicknesses were 148.33±23.22, 126.36±23.45, 82.21±22.30 and 83.36±31.28 µm in the superior, inferior, temporal and nasal quadrants, respectively. In the control group, the mean GCIPL thickness was 86.98±22.37 µm, the minimum GCIPL thickness was 85.28±10.75 µm, and the RNFL thicknesses were 150.22±22.73, 154.79±60.23, 82.33±7.01 and 85.62±13.81 µm in the superior, inferior, temporal and nasal quadrants, respectively. The GCIPL and RNFL were thinner in the NMO-ON contra group than in the control group (<0.05); additionally, the RNFL was thinner in the inferior quadrant in the NMO-ON group than in the control group (<0.05). Significant correlations were observed between the GCIPL and RNFL thickness measurements as well as between thickness measurements and the two visual field parameters of mean deviation (MD) and corrected pattern standard deviation (PSD) in the NMO-ON group (<0.05).
CONCLUSION
The thickness of the GCIPL and RNFL, as measured using OCT, may indicate optic nerve damage in patients with NMO.
目的
确定视神经脊髓炎（NMO）患者视网膜神经节细胞 - 内丛状层（GCIPL）和视网膜神经纤维层（RNFL）的厚度。
方法
我们进行了一项横断面研究，纳入30例NMO患者共60只眼。根据是否存在视神经炎（ON），将受试者分为NMO - ON组（30只眼）和NMO - ON对侧组（10只眼）。对每组进行详细的眼科检查；随后，使用高清光学相干断层扫描（OCT）测量GCIPL和RNFL。
结果
在NMO - ON组中，GCIPL平均厚度为69.28±21.12 µm，GCIPL最小厚度为66.02±10.02 µm，RNFL厚度在上方、下方、颞侧和鼻侧象限分别为109.33±11.23、110.47±3.10、64.92±12.71和71.21±50.22 µm。在NMO - ON对侧组中，GCIPL平均厚度为85.12±17.09 µm，GCIPL最小厚度为25.39±25.1 µm，RNFL厚度在上方、下方、颞侧和鼻侧象限分别为148.33±23.22、126.36±23.45、82.21±22.30和83.36±31.28 µm。在对照组中，GCIPL平均厚度为86.98±22.37 µm，GCIPL最小厚度为85.28±10.75 µm，RNFL厚度在上方、下方、颞侧和鼻侧象限分别为150.22±22.73、154.79±60.23、82.33±7.01和85.62±13.81 µm。NMO - ON对侧组的GCIPL和RNFL比对照组更薄（<0.05）；此外，NMO - ON组下方象限的RNFL比对照组更薄（<0.05）。在NMO - ON组中，观察到GCIPL和RNFL厚度测量值之间以及厚度测量值与平均偏差（MD）和校正模式标准偏差（PSD）这两个视野参数之间存在显著相关性（<0.05）。
结论
使用OCT测量的GCIPL和RNFL厚度可能表明NMO患者存在视神经损伤。
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